Recreating the biological pacemaker

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Michael R RosenIra S Cohen

Abstract

In recent years, several groups have reported a variety of strategies for developing biological pacemakers whose ultimate function would be to supplement/replace electronic pacemakers. Strategies have included gene therapy using naked plasmids or viral vectors and cell therapy for which both adult human mesenchymal stem cells (hMSCs) and human embryonic stem cells have been employed. This article reviews the various approaches and summarizes our own research in which the pacemaker gene, HCN2, is administered via viral vector or in an hMSC platform to produce pacemaker function in the intact canine heart.

References

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Feb 7, 1998·The Journal of Clinical Investigation·J M EdelbergR D Rosenberg
Oct 17, 2001·Heart·J M EdelbergR D Rosenberg
May 29, 2002·Tissue Engineering·Astrid HammAnja K Bosserhoff
Sep 13, 2002·Nature·Junichiro MiakeH Bradley Nuss
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Mar 5, 2003·Circulation·Jihong QuMichael R Rosen
Feb 10, 2004·The Journal of Physiology·Virginijus ValiunasIra S Cohen
Feb 28, 2004·Circulation Research·Irina PotapovaIra S Cohen

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Citations

Oct 19, 2006·Medical & Biological Engineering & Computing·Gerard J J BoinkHanno L Tan
Apr 19, 2011·Cardiac Electrophysiology Clinics·Jeffrey B Anderson, D Woodrow Benson
Apr 27, 2007·Journal of Molecular and Cellular Cardiology·S ViswanathanD W Benson
Jun 9, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Alfred A KocherGünther Laufer
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kurt H Albertine, Mari Dezawa
Nov 7, 2012·Journal of the American Heart Association·Caline S Karam, Fadi G Akar
Jan 31, 2007·Medical & Biological Engineering & Computing·Yuichi TomitaKeiichi Fukuda
Apr 3, 2008·The Journal of Gene Medicine·Gerard J J BoinkHanno L Tan
Jul 16, 2008·Physiological Reviews·Matteo E Mangoni, Joël Nargeot

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