Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Drug and Alcohol Dependence
Chun ChaoRoger Detels

Abstract

The effects of recreational drugs on CD4 and CD8 T cells in humans are not well understood. We conducted a longitudinal analysis of men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) to define associations between self-reported use of marijuana, cocaine, poppers and amphetamines, and CD4 and CD8 T cell parameters in both HIV-uninfected and HIV-infected MSM. For the HIV-infected MSM, we used clinical and laboratory data collected semiannually before 1996 to avoid potential effects of antiretroviral treatment. A regression model that allowed random intercepts and slopes as well as autoregressive covariance structure for within subject errors was used. Potential confounders adjusted for included length of follow-up, demographics, tobacco smoking, alcohol use, risky sexual behaviors, history of sexually transmitted infections, and antiviral therapy. We found no clinically meaningful associations between use of marijuana, cocaine, poppers, or amphetamines and CD4 and CD8 T cell counts, percentages, or rates of change in either HIV-uninfected or -infected men. The regression coefficients were of minimum magnitude despite some reaching statistical significance. No threshold effect was detected for fre...Continue Reading

References

Jan 1, 1991·Immunopharmacology and Immunotoxicology·E M DaxJ H Jaffe
Jan 1, 1991·Life Sciences·M Freire-GarabalA Belmonte
Mar 1, 1973·Archives of Environmental Health·G D FriedmanM F Collen
Apr 15, 1983·Journal of Immunological Methods·R E Chambers, J T Whicher
Mar 1, 1994·Clinical Immunology and Immunopathology·P RuizB Steele
Sep 21, 1995·The New England Journal of Medicine·R E ChaissonR D Moore
Mar 11, 1993·Nature·M S AscherE Vittinghoff
Jan 10, 1998·JAMA : the Journal of the American Medical Association·D VlahovH Farzadegan
Jun 4, 1998·Journal of Neuroimmunology·T W KleinS Specter
Jun 4, 1998·Journal of Neuroimmunology·T Pellegrino, B M Bayer
Aug 18, 2000·Immunopharmacology and Immunotoxicology·M Domingues-JuniorJ Palermo-Neto
Nov 5, 2002·Journal of Clinical Pharmacology·Barry M BredtDonald I Abrams
Aug 23, 2003·Biostatistics·R HendersonA Dobson
Jan 27, 2004·Journal of Neuroimmunology·Thomas W KleinHerman Friedman
Jul 1, 1996·Pharmacoepidemiology and Drug Safety·E P LarratK Mayer
Oct 16, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lorna E ThorpeRonald C Hershow
May 10, 2005·European Journal of Pharmacology·Myoungki Baek, Michael Weiss

❮ Previous
Next ❯

Citations

Aug 11, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Patricia E MolinaCurtis Vande Stouwe
Nov 13, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jasmine ShiraziPooja Jain
Feb 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joseph A PolitchDeborah J Anderson
Feb 8, 2014·PloS One·Ulisses Ramos MontarroyosRicardo Arraes de Alencar Ximenes
Mar 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jade GhosnUNKNOWN Evarist–ANRS EP 49 Study Group
Nov 26, 2008·The American Journal of Medicine·Clifford P MartinStephen A Klotz
Apr 4, 2016·Drug and Alcohol Dependence·Paola ZuluagaRoberto Muga
Aug 25, 2015·Frontiers in Public Health·Alexey Karetnikov
May 7, 2014·BioMed Research International·Dongliang LiYifei Hu
Nov 4, 2016·The American Journal of Drug and Alcohol Abuse·Chukwuemeka N OkaforMichael W Plankey
Jun 7, 2014·Experimental Biology and Medicine·Christina C MarascoJohn P Wikswo
Apr 28, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R LorenzDana Gabuzda
Nov 6, 2015·Frontiers in Microbiology·Sabyasachi DashJui Pandhare
Aug 14, 2019·AIDS·Cecilia T Costiniuk, Mohammad-Ali Jenabian
Nov 26, 2019·AIDS·Cecilia T Costiniuk, Mohammad-Ali Jenabian
Feb 16, 2021·Neuroscience Letters·Barkha J Yadav-Samudrala, Sylvia Fitting
May 2, 2021·AIDS and Behavior·Vanessa Castro-GranellMaría José Fuster-RuizdeApodaca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.