Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers

Journal of Psychopharmacology
David ErritzoeGitte M Knudsen

Abstract

Recent studies have suggested therapeutic benefits of psychedelics for a variety of mental health conditions. The understanding of how single psychedelic administrations can induce long-lasting effects are, in large, still lacking. However, recent studies in both healthy and clinical populations suggest a role for personality changes. To test support for some of these plausible mechanisms we evaluated (cross-sectional) associations between recreational use of psychedelics and 3,4-methylene-dioxymethamphetamine (MDMA) and (a) personality measures and (b) key markers of cerebral serotonergic signalling (serotonin transporter and serotonin-2A-receptor binding). In 10 psychedelic-preferring recreational users, 14 MDMA-preferring users and 21 non-using controls, personality was assessed using the 'big five' instrument Revised NEO Personality Inventory (NEO-PI-R). Frontal serotonin transporter and serotonin-2A-receptor binding potentials were quantified using [11C]DASB and [18F]altanserin positron emission tomography, respectively. Of the five NEO-PI-R traits, only openness to experience scores differed between the three groups; psychedelic-preferring recreational users showing higher openness to experience scores when compared with ...Continue Reading

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Citations

Jun 24, 2020·Human Psychopharmacology·Edward JamesBen Sessa
Feb 12, 2021·Journal of Psychopharmacology·Carla PallaviciniEnzo Tagliazucchi
Oct 31, 2020·Acta Psychiatrica Scandinavica·Kristoffer A A AndersenDavid Erritzoe
Apr 6, 2021·Biological Psychiatry·Harriet de WitMichael Bremmer
Apr 24, 2021·Social Cognitive and Affective Neuroscience·Maja Rou Marstrand-JoergensenPatrick M Fisher
Aug 6, 2021·Frontiers in Psychiatry·Rita KočárováRobin Carhart-Harris
Jul 25, 2021·Scientific Reports·Alexander V LebedevP Petrovic

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Methods Mentioned

BETA
pharmacotherapies

Software Mentioned

SPSS
lava
package
R

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