Recruitment and proliferation of CD4+ T cells in synovium following adoptive transfer of adjuvant-induced arthritis

International Immunology
Llewellyn D J SpargoGraham Mayrhofer

Abstract

Adjuvant-induced arthritis can be transferred to naive Dark Agouti (DA) strain (DA.CD45.1) rats by thoracic duct (TD) lymphocytes. Disease can be re-induced in convalescent rats by further transfer of arthritogenic cells, suggesting that resolution of the adoptive disease is not due to active regulation. To examine whether resolution is due to exhaustion of effector cells, we transferred the disease to DA.CD45.1 recipients, using CD4+ T cells from DA.CD45.2 donors. At the height of the adoptively transferred disease, donor cells comprised only 5-10% of recirculating CD4+ T cells but they accounted for approximately 40% of the CD4+ T cells in synovium-rich tissues of the hind paws. Approximately 65% of the donor cells in the synovium expressed a marker of proliferation (Ki-67 antigen). Division of CD4+ T cells continued in shielded paws after suppression of the recirculating pool of lymphocytes by selective irradiation. Intravenously injected CD4+ TD T lymphoblasts from arthritic donors were recruited to normal paws and, in greater numbers, to paws of animals with existing arthritis. Survival of the [125I]iodo-deoxyuridine-labeled lymphoblasts was greater in animals with existing arthritis. We conclude that effector CD4+ T cells...Continue Reading

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Citations

Mar 30, 2011·Immunology and Cell Biology·Mahin MoghaddamiLeslie G Cleland
Nov 22, 2007·Arthritis Research & Therapy·Mahin MoghaddamiGraham Mayrhofer
Oct 10, 2007·Expert Opinion on Investigational Drugs·Sara Bar-YehudaPnina Fishman
Apr 24, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Stephan FrickeUlrich Sack
Jan 10, 2012·The Journal of Pharmacology and Experimental Therapeutics·Daigen XuJay S Fine
Aug 7, 2008·Journal of Leukocyte Biology·Nicholas H E MabarrackGraham Mayrhofer

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