Recruitment and Retention in Clinical Trials of Deep Brain Stimulation in Early-Stage Parkinson's Disease: Past Experiences and Future Considerations

Journal of Parkinson's Disease
K Grace CannardDavid Charles

Abstract

Clinical trials are often hindered by inadequate patient recruitment. Overly optimistic investigator predictions of participation can lead to unmet recruitment goals and costly trial extensions. A patient-focused approach estimating recruitment in clinical trials may provide higher accuracy. To assess the feasibility of recruitment in a future deep brain stimulation (DBS) in early-stage Parkinson's disease (PD) multicenter trial by understanding motivations and concerns to participation of past and potential future DBS in early-stage PD clinical trial subjects. To identify motivating factors and barriers influencing trial participation, an end-of-trial survey was administered to subjects enrolled in a DBS in early-stage PD pilot trial with subjects randomized to receive DBS plus optimal drug therapy (DBS+ODT) or ODT alone (NCT#00282152, IDE#G050016). Pilot trial survey results were analyzed in conjunction with results of a previously-reported survey querying PD patients about potential participation in a trial for DBS in early-stage PD with similar inclusion/exclusion criteria. Pilot trial subjects reported high levels of satisfaction with their participation in the study. Similar motivations and barriers to participation were ...Continue Reading

References

Sep 30, 2005·Anesthesia and Analgesia·Elizabeth G VanDenKerkhofMichael J Rimmer
May 5, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Michael S RemplePeter E Konrad
Jul 1, 2011·Parkinsonism & Related Disorders·Anabela ValadasJoaquim J Ferreira
Sep 6, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Elyne KahnPeter Konrad
Nov 23, 2011·Parkinsonism & Related Disorders·P D CharlesP E Konrad
Mar 29, 2014·Frontiers in Neurology·Corrie R CamalierDavid Charles
Apr 29, 2014·Parkinsonism & Related Disorders·David CharlesThomas L Davis
Dec 6, 2014·Clinical Trials : Journal of the Society for Clinical Trials·Benjamin CarlisleNathalie MacKinnon
Dec 22, 2015·Parkinsonism & Related Disorders·Mi-Ryoung KimSun Ha Paek
Dec 3, 2016·Journal of Parkinson's Disease·Lauren HeusinkveldDavid Charles
Jan 14, 2018·Contemporary Clinical Trials·Grant D HuangUNKNOWN CTTI Recruitment Project Team

❮ Previous
Next ❯

Citations

Nov 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pavan A VaswaniNabila Dahodwala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.