Abstract
The purposes of this study were to evaluate if (1) Angiostrongylus vasorum-infected dogs recruit pulmonary arteriovenous (AV) shunts attenuating the development of pulmonary hypertension (PH), detectable using saline contrast echocardiography, (2) anthelmintic therapy causes an acute increase in pulmonary arterial pressure (PAP), (3) Tissue Doppler Imaging (TDI) allows detection of mild changes in right ventricular function secondary to pulmonary (vascular) disease. 6 healthy Beagle dogs, each infected with 200 A. vasorum larvae. Conventional, TDI and contrast echocardiography, invasive PAP measurements before (T0), 7-12 weeks post infection (wpi, T1), and 1-5 days post therapy (dpt, T2). All dogs had patent infections 7-8 wpi and respiratory signs 6-9 wpi. PAP was mildly but significantly increased at T2. Saline contrast echo was positive in 3/6 dogs at T1 and 4/6 dogs at T2. Pulmonary transit time did not change. Of all numeric echocardiographic parameters, only a non-significant decrease in the E' wave and inversion of E'/A' ratio in 3 dogs at T2 could be observed. Two of these had mild PH and negative saline contrast echocardiography. A. vasorum infection causes only a mild increase in PAP following inoculation and anthelmi...Continue Reading
References
Dec 22, 1999·European Radiology·M Schneider
Sep 5, 2002·The American Journal of Cardiology·Kenji HaradaKenji Yasuoka
Jan 1, 1956·Circulation Research·A H NIDEN, D M AVIADO
Dec 9, 2003·Journal of Veterinary Internal Medicine·Peter LordOlli Mäkelä
Apr 27, 2004·Journal of Applied Physiology·Marlowe W EldridgeJohn S Hokanson
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Michael K SticklandMarlowe W Eldridge
Dec 20, 2007·Critical Care Medicine·Massimo CressoniLuciano Gattinoni
Jan 25, 2008·Veterinary Parasitology·Donato TraversaCarlo Guglielmini
Feb 23, 2008·Journal of Applied Physiology·Andrew T LoveringMarlowe W Eldridge
Apr 19, 2008·Journal of the American College of Cardiology·Kelly M Chin, Lewis J Rubin
Apr 24, 2008·Critical Care Medicine·Steven C Reynolds, Juan J Ronco
Aug 9, 2008·The Journal of Physiology·Andrew T LoveringMarlowe W Eldridge
Oct 15, 2008·Cardiovascular Ultrasound·Luis R LopesManuel Carrageta
Jan 30, 2009·Journal of Veterinary Internal Medicine·S D JenniT M Glaus
Aug 29, 2009·Journal of Applied Physiology·Andrew T LoveringMichael K Stickland
May 25, 2010·Journal of Veterinary Internal Medicine·A KranjcT M Glaus
Aug 12, 2010·Parasitology Research·Manuela SchnyderPeter Deplazes
May 11, 2011·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Matthias DennlerTony M Glaus
Citations
Aug 12, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·José Novo-MatosTony Glaus
Dec 3, 2014·Indian Heart Journal·Ashfaq HasanSyed Mahmood
Aug 22, 2015·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Heidi B KellihanMelissa L Bates
Jan 25, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·J Novo MatosT Glaus
Dec 9, 2014·The Journal of Small Animal Practice·K BorgeatD J Connolly
Jun 4, 2015·Parasitology·M SchnyderP Deplazes
Nov 17, 2017·Parasites & Vectors·Randolph L WinterSharon Barney
Jun 6, 2019·Parasites & Vectors·Andrea CordaMaria Luisa Pinna Parpaglia
Sep 17, 2017·Parasites & Vectors·Nina Gillis-Germitsch, Manuela Schnyder
Feb 18, 2020·Journal of Veterinary Internal Medicine·Carol ReineroBrian A Scansen
Jan 24, 2021·Topics in Companion Animal Medicine·Paola ParadiesClaudio Maria Bussadori
Jan 13, 2021·Scientific Reports·Lucienne TrittenManuela Schnyder