Recruitment of arteriovenous pulmonary shunts may attenuate the development of pulmonary hypertension in dogs experimentally infected with Angiostrongylus vasorum

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
José M MatosT M Glaus

Abstract

The purposes of this study were to evaluate if (1) Angiostrongylus vasorum-infected dogs recruit pulmonary arteriovenous (AV) shunts attenuating the development of pulmonary hypertension (PH), detectable using saline contrast echocardiography, (2) anthelmintic therapy causes an acute increase in pulmonary arterial pressure (PAP), (3) Tissue Doppler Imaging (TDI) allows detection of mild changes in right ventricular function secondary to pulmonary (vascular) disease. 6 healthy Beagle dogs, each infected with 200 A. vasorum larvae. Conventional, TDI and contrast echocardiography, invasive PAP measurements before (T0), 7-12 weeks post infection (wpi, T1), and 1-5 days post therapy (dpt, T2). All dogs had patent infections 7-8 wpi and respiratory signs 6-9 wpi. PAP was mildly but significantly increased at T2. Saline contrast echo was positive in 3/6 dogs at T1 and 4/6 dogs at T2. Pulmonary transit time did not change. Of all numeric echocardiographic parameters, only a non-significant decrease in the E' wave and inversion of E'/A' ratio in 3 dogs at T2 could be observed. Two of these had mild PH and negative saline contrast echocardiography. A. vasorum infection causes only a mild increase in PAP following inoculation and anthelmi...Continue Reading

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Citations

Aug 12, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·José Novo-MatosTony Glaus
Aug 22, 2015·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Heidi B KellihanMelissa L Bates
Jan 25, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·J Novo MatosT Glaus
Sep 17, 2017·Parasites & Vectors·Nina Gillis-Germitsch, Manuela Schnyder
Jan 24, 2021·Topics in Companion Animal Medicine·Paola ParadiesClaudio Maria Bussadori

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

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