PMID: 9181060Sep 1, 1996Paper

Recruitment of brain macrophages: roles of cytokines and extracellular matrix proteins produced by glial or neuronal cells

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M MallatA Dobbertin

Abstract

Brain macrophages are a subpopulation of microglial cells which occur in the developing or in the injured CNS. These cells actively contribute to CNS tissue remodeling by acting on neuronal and macroglial lineages. Recruitment of brain macrophages is promoted by transformation of resting microglial phenotypes, infiltration of the tissue by exogenous macrophage precursors and local proliferation of phagocytes. These events are regulated by extracellular signals produced by glial cells or neurons. Studies based on in vitro cell cultures or experimental tissue lesions suggest that the infiltration of phagocytes involves intracerebral production of chemotactic factors acting on monocytes such as chemokines or extracellular matrix proteins. Proliferation of brain macrophages in stimulated by colony-stimulating factors which seem to be primarily secreted by glial cells.

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Trends in Neurosciences
Christian Steinhäuser, V Gallo
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
L Mucke, M Eddleston
Investigative Ophthalmology & Visual Science
Ortrud UckermannA Bringmann
© 2021 Meta ULC. All rights reserved