Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism

Movement Disorders : Official Journal of the Movement Disorder Society
Ken-Ichi InoueMasahiko Takada

Abstract

Parkinson's disease is caused by dopamine deficiency in the striatum, which is a result of loss of dopamine neurons from the substantia nigra pars compacta. There is a consensus that a subpopulation of nigral dopamine neurons that expresses the calcium-binding protein calbindin is selectively invulnerable to parkinsonian insults. The objective of the present study was to test the hypothesis that dopamine neuron degeneration might be prevented by viral vector-mediated gene delivery of calbindin into the dopamine neurons that do not normally contain it. A calbindin-expressing adenoviral vector was injected into the striatum of macaque monkeys to be conveyed to cell bodies of nigral dopamine neurons through retrograde axonal transport, or the calbindin-expressing lentiviral vector was injected into the nigra directly because of its predominant uptake from cell bodies and dendrites. The animals in which calbindin was successfully recruited into nigral dopamine neurons were administered systemically with MPTP. In the monkeys that had received unilateral vector injections, parkinsonian motor deficits, such as muscular rigidity and akinesia/bradykinesia, appeared predominantly in the limbs corresponding to the non-calbindin-recruited ...Continue Reading

References

Mar 1, 1991·Trends in Biochemical Sciences·C W Heizmann, W Hunziker
Nov 1, 1989·Trends in Neurosciences·A PersechiniR H Kretsinger
Jan 10, 1984·The Journal of Comparative Neurology·J Szabo, W M Cowan
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A N MurphyG Fiskum
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·L NaldiniI M Verma
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q GuoM P Mattson
Apr 4, 1998·Brain Research. Molecular Brain Research·A McMahonD C German
May 3, 2000·The European Journal of Neuroscience·M TakadaH Imai
May 11, 2000·Journal of Neurophysiology·C J Wilson, J C Callaway
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lars M BjorklundOle Isacson
Aug 2, 2002·European Journal of Pharmacology·Charles Krieger, Michael R Duchen
Jan 22, 2003·The European Journal of Neuroscience·Kati KühnChristine C Stichel
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Jan 5, 2005·The Journal of Clinical Investigation·Yasushi TakagiNobuo Hashimoto
Jul 12, 2005·Neurobiology of Disease·Maya G PurisaiDonato A Di Monte
Jul 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marina E EmborgDavid Eidelberg
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Jun 15, 2007·Nature·C Savio ChanD James Surmeier
Apr 17, 2008·Biochemical and Biophysical Research Communications·Won-Seok ChoiYoung J Oh
Mar 28, 2012·Annals of Neurology·Connie MarrasPeter C Austin
Mar 26, 2015·Frontiers in Neuroscience·Scarlet GallegosLuis G Aguayo
Sep 4, 2016·Biochemical and Biophysical Research Communications·D James SurmeierEnrico Zampese
Aug 7, 2017·Experimental Neurology·D James SurmeierTanya Simuni

❮ Previous
Next ❯

Citations

Jan 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Javier Blesa, Miquel Vila
Feb 23, 2019·Cells·Fleur A McLearyDean L Pountney
Oct 28, 2019·Frontiers in Molecular Neuroscience·Emmanouela LeandrouKostas Vekrellis
Oct 27, 2020·Frontiers in Neuroinformatics·Vignayanandam Ravindernath Muddapu, V Srinivasa Chakravarthy
May 22, 2021·Brain Structure & Function·S PetryszynM Parent
Jul 9, 2021·Frontiers in Pharmacology·Yiqiu LiuXuqiang Nie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.