Recruitment of extravascular fluid by hyperoncotic albumin

Acta Anaesthesiologica Scandinavica
M ZdolsekJ H Zdolsek

Abstract

Although hyperoncotic albumin may be used to recruit oedema, its effectiveness remains unclear. Therefore, this issue was studied during infusion experiments in healthy volunteers. Fifteen healthy volunteers (mean age 31 years) received an infusion of 3 mL/kg of 20% albumin over 30 minutes. Their urinary excretion was recorded, and venous blood samples were taken to measure blood haemoglobin (Hb), haematocrit, colloid osmotic pressure as well as plasma albumin and sodium concentrations on 15 occasions over a period of 300 minutes. Plasma volume expansion was taken as the inverse of the fluid-induced dilution of venous plasma, as given by the blood Hb concentration. Mass balance calculations were used to estimate the mobilisation of fluid from the tissues. Maximum plasma volume expansion was reached 20 minutes after completing an infusion of 20% albumin. Urinary excretion was effectively increased, and the mobilised fluid from the tissues at 300 minutes amounted to 3.4 ± 1.2 mL for each infused mL of 20% albumin, of which 19% was of intracellular origin. The urinary excretion correlated strongly with the amount of recruited fluid (R2  = 0.87) and inversely with the plasma volume expansion (R2  = 0.53). The infusion of 20% albumi...Continue Reading

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Citations

Feb 14, 2019·British Journal of Clinical Pharmacology·Robert G HahnHåkan Björne
Feb 16, 2019·Anesthesia and Analgesia·Emma HasselgrenRobert G Hahn
Dec 22, 2019·Acta Anaesthesiologica Scandinavica·Robert G Hahn
Apr 10, 2020·Acta Anaesthesiologica Scandinavica·C Charles MichelFitz-Roy E Curry
May 12, 2020·Acta Anaesthesiologica Scandinavica·Robert G Hahn, Randal O Dull
Feb 5, 2019·Clinical Hemorheology and Microcirculation·Robert G HahnJoachim Zdolsek
May 6, 2020·Critical Care : the Official Journal of the Critical Care Forum·Markus ZdolsekJoachim H Zdolsek
Dec 18, 2020·Frontiers in Veterinary Science·Xiu Ting YiewWilliam W Muir

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