PMID: 6976967Jan 1, 1982Paper

Recruitment of osteoclast precursors by purified bone matrix constituents

The Journal of Cell Biology
J D MaloneA J Kahn

Abstract

The osteoclast, the multinucleated giant cell of bone, is derived from circulating blood cells, most likely monocytes. Evidence has accrued that is consistent with the hypothesis that the recruitment of monocytes for osteoclast development occurs by chemotaxis. In the present study, we have examined the chemotactic response of human peripheral blood monocytes and related polymorphonuclear leucocytes to three constituents of bone matrix: peptides from Type I collagen, alpha 2-HS glycoprotein, and osteocalcin (bone gla protein). The latter two substances are among the major noncollagenous proteins of bone and are uniquely associated with calcified connective tissue. In chemotaxis assays using modified Boyden chambers, Type I collagen peptides, alpha 2HS glycoprotein, and osteocalcin evoke a dose-dependent chemotactic response in human monocytes. No chemotaxis is observed on PMNs despite their ontogenetic relationship to monocytes and their documented sensitivity to a broad range of other chemical substances. Our observations are consistent with the view that osteoclast precursors (monocytes) are mobilized by chemotaxis, and suggest that the chemoattractants responsible for this activity are derived from the bone matrix or, in the...Continue Reading

References

Nov 1, 1978·The Journal of Pathology·T J Chambers
Sep 14, 1978·Nature·G R MundyP A Ward
May 1, 1978·The Journal of Cell Biology·S H Zigmond
Dec 8, 1978·Calcified Tissue Research·J T TriffittJ M Wilson
Oct 20, 1977·Calcified Tissue Research·D J Rowe, E Hausmann
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P V HauschkaP M Gallop
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P A PriceN Raman
Sep 1, 1975·The Anatomical Record·B K Hall
Jun 1, 1976·The Journal of Experimental Medicine·A E Postlethwaite, A H Kang
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Apr 15, 1981·Biochemical and Biophysical Research Communications·P A Price, S A Baukol
Mar 27, 1980·The New England Journal of Medicine·P F CocciaD M Brown
Feb 14, 1980·Nature·P AshK M Townsend
Aug 1, 1962·The Anatomical Record·D A FISCHMAN, E D HAY

❮ Previous
Next ❯

Citations

Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D WebberM Krukowski
Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L PlantalechP D Delmas
Aug 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N M RitterW T Butler
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P T GuidonR S Bockman
Apr 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M D McKeeA Nanci
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G ColomboH H Malluche
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R J GalvinP A Osdoby
Mar 1, 1991·Journal of Cellular Biochemistry·J GlowackiJ Lian
Jul 1, 1994·Journal of Cellular Biochemistry·I A Bab, T A Einhorn
Jan 1, 1992·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·K M DziegielewskaN R Saunders
Jan 1, 1990·Archives of Orthopaedic and Trauma Surgery·M R SarkarS M Perren
Jan 1, 1993·Breast Cancer Research and Treatment·F W OrrG Singh
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·T OhtaS Ishii
Apr 1, 1987·Cell and Tissue Research·L M Walters, G B Schneider
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·G BoivinP J Meunier
Jan 1, 1983·Calcified Tissue International·G R Mundy, J W Poser
Jul 1, 1983·Calcified Tissue International·M SomermanA H Reddi
Jul 1, 1990·Calcified Tissue International·T A HentunenH K Väänänen
May 1, 1991·Calcified Tissue International·B Groessner-SchreiberP Osdoby
Jan 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K HenriksenM A Karsdal
Dec 6, 2008·Journal of Bone and Mineral Metabolism·Cristina VincentGerald J Atkins
Feb 1, 1992·Mechanisms of Ageing and Development·B Groessner-SchreiberP Osdoby
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D L CoxO J Sexton
Jan 20, 2004·Seminars in Nephrology·Keith A HruskaKameswaran Surendran
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M HorowitzR Baron
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D MaloneA J Kahn
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C C LeeF M Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.