Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae)

Synapse
Rafael Carvalho Almada, N C Coimbra

Abstract

The neuropsychopharmacological basis of fear- or panic-related behavior has been the focus of several studies. Some mesencephalic tectum (MT) structures, such as the superior colliculus (SC) and dorsal periaqueductal gray matter (dPAG), are considered to be responsible for the control of defensive responses evoked during threatening situations. Furthermore, the pars reticulata of the substantia nigra (SNpr) sends inputs to the SC that can work as a sensory channel to MT neurons fundamental for the elaboration of defensive responses. The purpose of the present study was to investigate the role of striato-nigral GABAergic inputs in the activity of nigro-tectal outputs during the elaboration of defensive behavior using a GABA(A) receptor selective blockade in the MT of mice confronted pre-treated with Bothrops alternatus. Mice with injections of physiological saline into the SNpr and treated with a GABA(A) receptor selective antagonist in the MT displayed an increase in panic-related behavior, expressed by an increase in the duration of freezing, frequency of nonoriented escape and frequency of total escape responses during the confrontation with the snake. However, intra-SNpr injections of cobalt chloride followed by MT injection...Continue Reading

References

Jan 1, 1990·Neuroscience and Biobehavioral Reviews·M L BrandaoP C Borges
Jan 1, 1988·Annual Review of Psychology·D C Blanchard, R J Blanchard
Jul 1, 1986·Behavioural Brain Research·F G GraeffM T Schütz
Nov 1, 1986·Behavioural Brain Research·F G GraeffM T Schütz
Jan 1, 1969·Journal of Neurosurgery·B S NasholdD G Slaughter
Oct 1, 1983·Physiology & Behavior·L C SchenbergF G Graeff
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·G Di ScalaP Karli
Jul 10, 1982·The Journal of Comparative Neurology·I GrofovaS T Kitai
Feb 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·G GriebelR J Blanchard
Dec 14, 1999·Neuroscience and Biobehavioral Reviews·M L BrandãoV M Castilho
May 30, 2001·Neuroscience and Biobehavioral Reviews·D C BlanchardR J Blanchard
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·Neil McNaughton, Philip J Corr
Jan 28, 2005·Cellular and Molecular Neurobiology·Renê Oliveira BeleboniNorberto Cysne Coimbra
Aug 9, 2005·Neuroscience and Biobehavioral Reviews·Marcus Lira BrandãoRaquel Chacon Martinez
Nov 18, 2005·Neuroscience and Biobehavioral Reviews·David B Adams
Sep 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrés Uribe-MariñoNorberto Cysne Coimbra

❮ Previous
Next ❯

Citations

Jan 13, 2016·BMC Evolutionary Biology·Alex Cagan, Torsten Blass
Nov 5, 2016·Neuropharmacology·Luiz Luciano Falconi-SobrinhoNorberto Cysne Coimbra
Feb 9, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Norberto C CoimbraBruno Lobão-Soares
Jun 6, 2018·PLoS Biology·Kazutaka MaedaOkihide Hikosaka
Dec 18, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ila M P LinaresJosé A Crippa
Jun 15, 2021·Neuroscience·Victor P M N SoaresRafael C Almada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

© 2022 Meta ULC. All rights reserved