Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study

Epilepsy & Behavior Case Reports
Dima SafiAnne Gallagher

Abstract

In a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the lexical one. Here, we seek to localize the epileptogenic focus in the same patient as a function of reading pathway using multimodal neuroimaging. The participant read irregular words and nonwords presented in a block-design paradigm during magnetoencephalography (MEG), functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) recordings, all combined with EEG. Spike analyses from MEG, fNIRS, and fMRI-EEGs data revealed an epileptic focus in the left precentral gyrus, and spike localization did not differ in lexical and phonological reading. This study is the first to investigate ictogenesis in reading epilepsy during both lexical and phonological reading while using three different multimodal neuroimaging techniques. The somatosensory and motor control functions of the left precentral gyrus that are congruently involved in lexical as well as phonological reading can explain the identical spike localizat...Continue Reading

References

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Apr 5, 2011·Epilepsy & Behavior : E&B·Dima SafiRenée Béland
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Mar 21, 2012·Brain and Language·Ayano Moriai-IzawaEiju Watanabe
Nov 22, 2012·Brain and Behavior·Dima SafiRenée Béland
Jan 5, 2013·Seizure : the Journal of the British Epilepsy Association·Francesca AnzellottiMarco Onofrj
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe

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