Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise

Neurobiology of Disease
Zhuo WangD P Holschneider

Abstract

Exercise modality and complexity play a key role in determining neurorehabilitative outcome in Parkinson's disease (PD). Exercise training (ET) that incorporates both motor skill training and aerobic exercise has been proposed to synergistically improve cognitive and automatic components of motor control in PD patients. Here we introduced such a skilled aerobic ET paradigm in a rat model of dopaminergic deafferentation. Rats with bilateral, intra-striatal 6-hydroxydopamine lesions were exposed to forced ET for 4weeks, either on a simple running wheel (non-skilled aerobic exercise, NSAE) or on a complex wheel with irregularly spaced rungs (skilled aerobic exercise, SAE). Cerebral perfusion was mapped during horizontal treadmill walking or at rest using [(14)C]-iodoantipyrine 1week after the completion of ET. Regional cerebral blood flow (rCBF) was quantified by autoradiography and analyzed in 3-dimensionally reconstructed brains by statistical parametric mapping. SAE compared to NSAE resulted in equal or greater recovery in motor deficits, as well as greater increases in rCBF during walking in the prelimbic area of the prefrontal cortex, broad areas of the somatosensory cortex, and the cerebellum. NSAE compared to SAE animals sh...Continue Reading

References

Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K R IsaacsW T Greenough
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E BlackW T Greenough
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C JonesS A Marshall
Jan 1, 1997·Neurobiology of Learning and Memory·J A KleimW T Greenough
Jan 4, 2001·American Journal of Physical Medicine & Rehabilitation·T A ScandalisM R Wells
Dec 26, 2001·Neurobiology of Learning and Memory·Michael E RagozzinoRaymond P Kesner
Jul 3, 2002·Nature Reviews. Neuroscience·M Angela CenciTimothy Schallert
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·D P HolschneiderO U Scremin
Apr 2, 2003·Brain Research. Cognitive Brain Research·Katja WerheidD Yves von Cramon
Apr 5, 2003·Journal of Neurochemistry·Ann D CohenMichael J Zigmond
Apr 26, 2003·The European Journal of Neuroscience·Céline RisterucciMarianne Amalric
Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D P HolschneiderO U Scremin
Dec 4, 2003·Behavioural Brain Research·Harry B M UylingsBryan Kolb
Mar 10, 2004·Journal of Cognitive Neuroscience·Rachael D Seidler
Feb 18, 2005·Journal of Neurophysiology·A Floyer-Lea, P M Matthews
Mar 26, 2005·Brain Research. Molecular Brain Research·Ciaran J FahertyRichard J Smeyne
Apr 16, 2005·Current Opinion in Neurobiology·Julien Doyon, Habib Benali
Jun 17, 2005·Brain : a Journal of Neurology·Tao Wu, Mark Hallett
Jul 23, 2005·The Journal of Physiology·Jukka KemppainenJuhani Knuuti
Sep 15, 2005·Behavioural Brain Research·Fleur M HowellsLauriston A Kellaway
Nov 9, 2005·Current Opinion in Neurobiology·Tamar Flash, Binyamin Hochner
Jun 23, 2006·Journal of Neurophysiology·Benjamin R TownsendRoger N Lemon
Dec 6, 2006·Neuron·Nandakumar S Narayanan, Mark Laubach
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giselle M PetzingerMichael W Jakowec
Jun 8, 2007·The European Journal of Neuroscience·Michelle PloughmanDale Corbett
Feb 16, 2008·Neuromolecular Medicine·Teresa E Foley, Monika Fleshner
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atsuko Nagano-SaitoAlain Dagher
Dec 9, 2008·Behavioural Brain Research·Julien DoyonHabib Benali
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard W Balleine, John P O'Doherty

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Citations

Sep 14, 2017·Neuroreport·Yumei GuoDaniel P Holschneider
Jan 10, 2018·Frontiers in Neuroscience·Dusica BajicLino Becerra
Dec 23, 2017·GeroScience·Joanna M S DaviesKelvin J A Davies
Jul 1, 2018·Reviews in the Neurosciences·Jenny Berrío SánchezAlcyr Alves de Oliveira
Nov 23, 2017·Frontiers in Aging Neuroscience·Lijuan HouFu-Ming Zhou
Oct 31, 2019·Nature Communications·Emily E NobleScott E Kanoski
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Baozhu FanJianshe Wei
Jan 26, 2020·Life Sciences·Ya-Shuo FengFeng Zhang
Feb 16, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stellina Y H LeeSusannah J Tye
Jun 9, 2021·Hippocampus·Sarah L AghjayanKirk I Erickson

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