Rectal and Urethro-Vesical Subregions for Toxicity Prediction After Prostate Cancer Radiation Therapy: Validation of Voxel-Based Models in an Independent Population.

International Journal of Radiation Oncology, Biology, Physics
Eugenia MylonaRenaud de Crevoisier

Abstract

Recent voxel-based studies have shown that the dose to specific rectal and urethro-vesical subregions is predictive of toxicities after prostate cancer intensity modulated radiation therapy. The objective of this study was to validate the discriminatory power of these subregions with respect to the whole organs in a large independent population. The validation cohort consisted of 450 patients from the TROG03.04-RADAR trial treated with 3-dimensional conformal radiation therapy at 66 to 74 Gy. Previous voxel-based analyses identified an inferoanterior rectal subregion as predictive of rectal bleeding and 5 subregions in the urethra and the posterior and superior part of the bladder as predictive of urinary incontinence, dysuria, retention, and hematuria. In the validation cohort, these subregions were segmented in each patient's anatomy. Dose-volume histograms (DVHs) of the whole organs and the 6 subregions were compared bin-wise between patients with and without toxicities. The discriminatory power of DVHs for grade ≥2 toxicity endpoints was assessed using the area under the receiver operating characteristic curve (AUC). Subregion DVHs were significantly different between patients with and without toxicities for late rectal ble...Continue Reading

References

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Mar 20, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mohamed NassefRenaud de Crevoisier
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Aug 3, 2018·International Journal of Radiation Oncology, Biology, Physics·Renaud de CrevoisierJean Léon Lagrange
Feb 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Eugenia MylonaRenaud de Crevoisier
Apr 1, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eugenia MylonaRenaud de Crevoisier

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Citations

Jan 28, 2021·Cancers·Daniëlle C VoshartLara Barazzuol
May 29, 2021·Physics in Medicine and Biology·Martin A EbertClaudio Fiorino
Apr 12, 2021·Journal of Vascular and Interventional Radiology : JVIR·Samdeep K MouliRiad Salem
Aug 19, 2021·International Journal of Radiation Oncology, Biology, Physics·Harald Paganetti

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