PMID: 428826Feb 1, 1979Paper

Rectal biopsy in patients presenting to an infectious disease unit with diarrhoeal disease

Gut
R J DickinsonD B McClelland

Abstract

The role of sigmoidoscopy and rectal biopsy was investigated in patients referred to an infectious diseases unit with diarrhoea. Seventy-four patients were studied. Nine patients (12%) had inflammatory bowel disease, either ulcerative colitis or Crohn's disease. Thirty-six patients (48%) had infective diarrhoea. A wide variety of conditions accounted for the diarrhoea in the remaining patients. Sigmoidoscopy was abnormal in 25 patients and rectal biopsy in 56. The abnormalities in rectal mucosal histology were classified into six grades. Some patients with infective diarrhoea showed rather characteristic histological changes which may be of diagnostic value. Eight showed features which suggested a diagnosis of inflammatory bowel disease. However, repeat rectal biopsy in the convalescent period showed a striking improvement in the patients with infective diarrhoea. In contrast, the histological changes persisted in the patients with inflammatory bowel disease. Repeat rectal biopsy may be essential before making a firm diagnosis of inflammatory bowel disease in some patients who present with diarrhoea and apparently typical histological changes.

References

Mar 1, 1978·Histopathology·D W DayB C Morson
Jan 1, 1977·Journal of Clinical Pathology·A B Price, D R Davies
Feb 23, 1974·British Medical Journal·B Mandal

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Citations

Dec 1, 1987·Digestive Diseases and Sciences·D A Malatjalian
Jan 1, 1983·The Journal of Pediatrics·S GuandaliniA Rubino
Jan 1, 1981·Archives of Disease in Childhood·D C CandyJ T Harries
Aug 4, 1984·British Medical Journal·C D Holdsworth
May 1, 1981·Gut·J JewkesH A Davies
Apr 1, 1984·Gut·A McMillanG R Scott
Oct 1, 1979·Journal of Clinical Pathology·C P WilloughbyS C Truelove
Oct 1, 1979·Journal of Clinical Pathology·A B PriceP J Sanderson
Jun 1, 1980·Journal of Clinical Pathology·R J DickinsonA T Axon
Aug 1, 1986·Postgraduate Medical Journal·D P Sellu
Aug 1, 1987·Postgraduate Medical Journal·G F BenfieldP Asquith
Aug 1, 1983·The British Journal of Venereal Diseases·A McMillanG J McNeillage
Mar 1, 1994·Gastrointestinal Endoscopy·T MatsumotoM Fujishima
Jul 1, 1985·The Journal of Pathology·M M Mathan, V I Mathan
Apr 24, 2001·The American Journal of Gastroenterology·R J ShahR A Giannella
Sep 1, 1980·Diseases of the Colon and Rectum·P J Milewski, M H Irving
Nov 10, 1984·British Medical Journal·D C Candy
Jan 1, 1983·Scandinavian Journal of Gastroenterology·P RolnyR Möllby
Oct 1, 1982·Scandinavian Journal of Gastroenterology·B K MandalB C Morson
Mar 1, 1985·Journal of the Royal Society of Medicine·A S MeeM Burke
Apr 1, 1993·Alimentary Pharmacology & Therapeutics·A J LoboA T Axon
Apr 1, 1990·Alimentary Pharmacology & Therapeutics·D A BurkeR W Lacey
Nov 1, 1982·Human Pathology·H Goldman, D A Antonioli

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