Rectal Cancer in a Patient with Bartter Syndrome: A Case Report

Genes
Shiki FujinoMasaki Mori

Abstract

A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient's BS, which became more manageable after tumor resection.

References

Sep 20, 1997·European Journal of Pediatrics·W Proesmans
Jul 9, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-Soriano
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Rosa Vargas-PoussouCorinne Antignac
Mar 27, 2004·The New England Journal of Medicine·Karl P SchlingmannSiegfried Waldegger
Aug 25, 2005·Gut·D Wang, R N Dubois
Aug 13, 2008·Nature Clinical Practice. Nephrology·Hannsjörg W Seyberth
Oct 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Murim ChoiRichard P Lifton
Oct 18, 2011·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Dec 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David TougeronFrank A Sinicrope

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Methods Mentioned

BETA
surgical resection
biopsy

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