Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Kyle T BernsteinJeffrey D Klausner

Abstract

HIV infection continues to disproportionately affect men who have sex with men (MSM). Identification of modifiable risk factors for HIV infection among MSM is critical for effective prevention. We examined the relationship between number of prior rectal Neisseria gonorrhoeae (GC) or Chlamydia trachomatis (CT) infections and HIV seroconversion in a retrospective cohort of HIV-uninfected MSM diagnosed with a rectal infection. Number of rectal CT or GC infections in the prior 2 years was the primary exposure. Univariate and multivariate Cox proportional hazards models were used to estimate the association between prior rectal infections and HIV seroconversion. A total of 541 MSM were observed for a total of 1197.96 person-years. Overall, 27 (4.99%) of the MSM became infected with HIV, for an estimated annual incidence of 2.25% [95% confidence interval (CI): 1.49 to 3.26]. In multivariate analysis, an early syphilis diagnosis in the past 2 years (hazard ratio = 4.04, 95% CI: 1.19 to 13.79) and 2 prior CT or GC rectal infections in the past 2 years (hazard ratio = 8.85, 95% CI: 2.57 to 30.40) were associated with incident HIV. Among MSM infected with rectal GC or CT, a history of 2 additional prior rectal infections was associated w...Continue Reading

References

Jan 1, 1989·American Journal of Epidemiology·R M Mickey, S Greenland
Oct 1, 1988·American Journal of Epidemiology·R A CoatesC L Soskolne
Jun 1, 1987·American Journal of Epidemiology·A R MossJ Carlson
Jan 1, 1995·Sexually Transmitted Diseases·J M ZenilmanD Celentano
Jul 1, 1995·The Journal of Infectious Diseases·K H RamseyC D Deal
Dec 1, 1993·American Journal of Epidemiology·G Maldonado, S Greenland
Apr 1, 1997·AIDS·M Morris, M Kretzschmar
Jan 7, 1998·The Journal of Infectious Diseases·W C LevineD F Talkington
Mar 20, 2002·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Scott D RhodesLeland J Yee
Sep 20, 2002·Sexually Transmitted Infections·R L CookC R Rinaldo
Nov 5, 2002·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Donald E MoriskyCarl D Sneed
Nov 5, 2002·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Grace E MacalinoDavid Vlahov
Jun 3, 2004·JAMA : the Journal of the American Medical Association·Rupert KaulUNKNOWN Kibera HIV Study Group
Dec 17, 2004·International Journal of STD & AIDS·M ChauhanR S Pattman
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlotte K KentJeffrey D Klausner
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicola M Zetola, Jeffrey D Klausner
Sep 9, 2008·The Journal of Clinical Investigation·Marein A W P de JongTeunis B H Geijtenbeek
Jan 22, 2009·AIDS·Susan ScheerWilli McFarland
Apr 16, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nicola M ZetolaJeffrey D Klausner

❮ Previous
Next ❯

Citations

Dec 18, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·A J Schmidt, U Marcus
Jun 27, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Preeti PathelaJulia A Schillinger
Jan 11, 2011·The Journal of Infectious Diseases·Aimee MerinoRichard A Kaslow
Jun 15, 2010·Current Opinion in HIV and AIDS·Helen Ward, Minttu Rönn
Sep 21, 2013·BMC Infectious Diseases·Maria XiridouMarianne A B van der Sande
Aug 21, 2013·American Journal of Public Health·E Claire NewbernDonald F Schwarz
Aug 17, 2011·International Journal of Women's Health·Cheryl K Walker, Richard L Sweet
Mar 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica E PattonHillard Weinstock
Jun 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marc M SolomonUNKNOWN iPrEx Study Team
Apr 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F Y S KongJ S Hocking
Nov 15, 2014·Journal of the International AIDS Society·Isabel Pérez-HernándezJesús Santos
Nov 6, 2015·International Journal of Molecular Sciences·Yinfeng ZhangStephen Kwok-Wing Tsui
Dec 22, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M BissessorM Y Chen
Apr 17, 2012·International Journal of Inflammation·John J Schellenberg, Francis A Plummer
Sep 4, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan E VolkC Bradley Hare
Jan 17, 2014·American Journal of Reproductive Immunology : AJRI·Ruizhong Shen, Phillip D Smith
Apr 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Preeti PathelaJulia A Schillinger
May 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sachin JainKenneth H Mayer
Mar 27, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Q M TrinhB J Marais
Mar 26, 2014·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Huachun ZouMarcus Y Chen
Nov 6, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melanie BissessorMarcus Y Chen
Aug 8, 2013·Sexually Transmitted Infections·Sandra Dudareva-VizuleUNKNOWN PARIS study group
May 18, 2016·Epidemiology and Infection·F Y S KongJ S Hocking
Jul 2, 2016·Infectious Diseases in Obstetrics and Gynecology·Philip A ChanErica J Hardy
Jun 17, 2016·AIDS and Behavior·Lina M NerlanderGabriela Paz-Bailey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.