PMID: 9662763Jul 15, 1998Paper

Rectal microbicides for U.S. gay men. Are clinical trials needed? Are they feasible? HIVNET Vaccine Preparedness Study Protocol Team

Sexually Transmitted Diseases
M GrossG R Seage

Abstract

Incomplete condom use during anal sex persists among gay men; microbicides may provide additional protection. Despite the absence of efficacy or safety data, many gay men use sexual lubricants containing nonoxynol-9 (N-9), a detergent-based spermicide under evaluation for efficacy as a vaginal microbicide. Evaluate unprotected sex, lubricant use, and attitudes regarding possible participation in clinical trials of rectal microbicides among high-risk human immunodeficiency virus-(HIV) seronegative U.S. gay men in six cities. A total of 3,257 gay men were interviewed and responded to a self-administered questionnaire at enrollment into a longitudinal cohort study of HIV seroincidence. Among 2,216 men who practiced receptive anal intercourse in the previous 6 months, 438 (20%) reported they never used condoms. More than three fourths of 3,093 men who had anal sex used lubricants more than 80% of the time. 41% of whom actively sought N-9 containing products. About two thirds said they were definitely or probably willing to participate in rectal microbicide clinical trials. Condom use is imperfect among men who report anal sex. N-9 lubricants are popular. Most gay men in this cohort indicate willingness to participate in rectal micr...Continue Reading

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Citations

Sep 22, 2001·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·R J WolitskiC A Gómez
Jun 10, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pamina M GorbachSusan J Little
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Jun 15, 2010·Current Opinion in HIV and AIDS·Gita Ramjee
Feb 2, 2016·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·J BauermeisterA Carballo-Diéguez
Oct 9, 2002·Sexually Transmitted Diseases·Dorothy L PattonSharon L Hillier
May 30, 2003·American Journal of Public Health·Michael Gross
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Apr 18, 2009·Current Opinion in HIV and AIDS·Ian McGowan, Peter Anton
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Dec 2, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pamina M GorbachSusan J Little
Oct 20, 2018·Journal of the International AIDS Society·Suzanne DayJoseph D Tucker
Feb 19, 2011·AIDS and Behavior·Ian McGowan
Mar 28, 2006·Sexually Transmitted Diseases·Oliver BaconKimberly Page-Shafer
Oct 4, 2012·Current Opinion in HIV and AIDS·Ian McGowan
Aug 4, 2004·Contraception·David M PhillipsRobin A Maguire

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