Rectal Mucinous Adenocarcinoma: MR Imaging Assessment of Response to Concurrent Chemotherapy and Radiation Therapy-A Hypothesis-generating Study

Radiology
Seung Hyun ParkHonsoul Kim

Abstract

Purpose To develop a system for assessment of tumor regression grade (TRG) with magnetic resonance (MR) imaging that is applicable to rectal mucinous adenocarcinoma (RMAC) and to obtain a preliminary evaluation of the association of MR imaging assessment of TRG with response to preoperative concurrent chemotherapy and radiation therapy (CCRT). Materials and Methods This retrospective study was approved by the institutional review board, and informed consent was waived. Pre- and post-CCRT MR images of 59 patients with RMAC (median age, 59 years; range, 29-80 years; 42 men [median age, 59 years; range, 36-80 years] and 17 women [median age, 57 years; range, 29-79 years]) who underwent CCRT and subsequent elective resection from July 2005 to June 2015 were analyzed. Two experienced gastrointestinal radiologists independently analyzed imaging parameters such as T stage, mesorectal fascia status, extramural vascular invasion status, and TRG by using modified criteria developed for assessment of RMAC. Interobserver variability was calculated with weighted κ analysis, and disagreement was settled in consensus. MR imaging TRG results were compared with those from pathologic TRG analysis (Mandard grade). Logistic regression analyses wer...Continue Reading

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Citations

Feb 14, 2019·Insights Into Imaging·Doenja M J LambregtsRegina G H Beets-Tan
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Nieun SeoJoon Seok Lim
Apr 18, 2019·Abdominal Radiology·Natally HorvatIva Petkovska
Mar 3, 2021·Abdominal Radiology·Renata R AlmeidaStuart G Silverman
May 25, 2020·Seminars in Ultrasound, CT, and MR·Supreeta AryaTarun Pandey

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