PMID: 6159132Nov 1, 1980Paper

Rectal mucosal histamine release in ulcerative colitis

Clinical Science
D S RamptonG E Sladen

Abstract

1. Rectal dialysis in vivo was used to assess rectal mucosal release of histamine in patients with ulcerative colitis and in control subjects. 2. Rectal mucosal histamine release was significantly increased in ulcerative colitis, whether the patients were in remission or relapse. The highest values were found in active colitis, but in several such patients histamine release was within the control range. Measurement of rectal mucosal electrical potential difference suggested that increased mucosal histamine release in this group of patients was not due to enhanced epithelial permeability. 3. Rectal dialysis appears to be a useful method for assessing mucosal histamine production and the results obtained are consistent with the hypothesis that immediate hypersensitivity reactions could be of importance in some patients with ulcerative colitis.

Citations

Mar 17, 2001·Scandinavian Journal of Gastroenterology·M RaithelE G Hahn
Nov 1, 1981·Diseases of the Colon and Rectum·N I McNeil, D S Rampton
May 31, 2008·The American Journal of Gastroenterology·Joel E MawdsleyDavid S Rampton
Jan 19, 2007·Inflammatory Bowel Diseases·James JuppAnthony P Sampson

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