Rectal tone, distensibility, and perception: reproducibility and response to different distensions

The American Journal of Physiology
H F HammerR B Hanson

Abstract

Increasing interest is focusing on the role of intestinal tone, distensibility, and mechanosensation in the genesis of abdominal symptoms. Experimental approaches usually feature balloon distension of the bowel with measurements of perception, tone, and compliance and/or elastance; however, the methodologies are standardized incompletely. We examined the reproducibility of repeated assessments of sensory perception, basal tone, and compliance and/or elastance of the rectum during distension. We also evaluated the response to inflations that varied in regard to control of pressure or volume, pattern of distension, and rate of inflation. Five healthy volunteers were studied under two separate protocols. The first featured a series of experiments on each of 5 days; the other consisted of 2 separate days of study. Repeated distensions evoked reproducible responses of sensation and compliance and/or elastance on a single day, providing a conditioning distension preceded them. Day-to-day variability was also sufficiently small to allow valid comparisons to be made on different days in healthy persons. The configuration of the distension profile (phasic, staircase, or ramp) and the rate of inflation (from 1 to 40 ml/s) had little effe...Continue Reading

References

Aug 1, 1991·Gastroenterology·C J SteadmanR B Hanson
Dec 1, 1990·Gastroenterology·E A Mayer, H E Raybould
May 1, 1990·Gastroenterology·W E WhiteheadM M Schuster
Mar 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T P TomaN J Talley

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Citations

Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·N M LawA R Zinsmeister
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Somchai LeelakusolvongAdil E Bharucha
May 31, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriAlan R Zinsmeister
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Seth SweetserAlan R Zinsmeister
Jul 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Delgado-ArosIrene Busciglio
Apr 25, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N MirbagheriM A Gladman
Jun 2, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M SharmaA E Bharucha
Mar 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Delgado-ArosAlan R Zinsmeister
Feb 21, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C NgJ E Kellow
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christopher AndrewsA R Zinsmeister
May 25, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thomas Dahl NissenAsbjørn Mohr Drewes
Jan 24, 2018·World Journal of Gastroenterology : WJG·De-Rong LiuShu-Kun Yao
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriAlan R Zinsmeister
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriRichard G Boles
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B E ViramontesA R Zinsmeister
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A E BharuchaA R Zinsmeister
May 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M L HarrisQ Aziz
Jan 20, 2006·Diseases of the Colon and Rectum·Mark FoxWerner Schwizer
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tuba EsfandyariAlan R Zinsmeister
May 17, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C BrockA M Drewes
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ngai-Moh LawAlan R Zinsmeister
May 19, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·D KeszthelyiA A Masclee
Oct 22, 2015·Journal of Neurogastroenterology and Motility·Andres AcostaAlan R Zinsmeister
Oct 10, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Georgios MavroudisMagnus Simrén

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