Recurrence Is a Noticeable Cause of Rifampicin-Resistant Mycobacterium tuberculosis in the Elderly Population in Jiangxi, China

Frontiers in Public Health
Qiang ChenKaisen Chen

Abstract

Setting: Rifampicin-resistant tuberculosis (RR-TB) in elderly people in Jiangxi Province, China. Objective: To investigate the incidence of RR-TB and risk factors in elderly people within a hospital setting in China. Design: Retrospective cohort study. Methods: A comparative study was performed to analyze RR-TB and rifampicin-susceptible TB (RS-TB). The 15-locus mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR) method was used to distinguish between relapse and reinfection. Results: Twenty-three recurrent cases occurred in 151 elderly patients with RR-TB, and 24 recurrent cases occurred in 466 elderly patients with RS-TB during this period. TB recurrence was significantly different in the RR-TB and RS-TB groups (OR = 0.35, 95% CI: 0.14-0.88; χ2 = 5.28, P = 0.03). Comparing the risk factors for RR-TB and RS-TB, we found that educational level, age, and pulmonary cavity were inextricably linked to RR-TB in elderly patients. Furthermore, pulmonary cavity, HIV status, and alcohol consumption were associated with recurrence in elderly RR-TB patients. Conclusions: Recurrence is an important source of RR-TB in the elderly population. It is necessary to promptly treat tuberculosis patients, preven...Continue Reading

References

Oct 13, 2006·The New England Journal of Medicine·Michael D Iseman, Leonid B Heifets
Apr 20, 2007·The Journal of Antimicrobial Chemotherapy·Maxim V Afanas'evVadim M Govorun
Feb 4, 2010·The Journal of Infectious Diseases·Sujatha NarayananParanji Raman Narayanan
May 12, 2011·The Journal of Antimicrobial Chemotherapy·Pedro Eduardo Almeida Almeida Da Silva, Juan Carlos Palomino
Nov 29, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R LanQ Gao
Mar 28, 2012·Antimicrobial Agents and Chemotherapy·Ajay PoudelYasuhiko Suzuki
Jun 8, 2012·The New England Journal of Medicine·Yanlin ZhaoYu Wang
Oct 24, 2014·BMC Infectious Diseases·Gisela UnisMaria Lucia Rosa Rossetti
Dec 22, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K-S ChenG-C Xiong
May 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Faiz Ahmad KhanSalmaan Keshavjee
Oct 30, 2016·Alcohol·Samantha M YeligarLou Ann S Brown
Feb 27, 2017·Tuberculosis·Lucia Monserrat Perez-NavarroRoberto Zenteno-Cuevas
May 26, 2017·Revista Brasileira De Reumatologia·José Cleosmaque Leite JúniorTeresa Cristina Martins Vicente Robazzi
Aug 5, 2017·International Journal of Mycobacteriology·Zheng QiYan-Fu Wang
Nov 21, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hyunsuk Frank RohJung Mogg Kim
Feb 24, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L G NgwiraK Fielding
Mar 23, 2018·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K K K HtetS T Aung
May 15, 2018·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Peiling YapCynthia Bin Eng Chee
Jun 6, 2018·Biomedical and Environmental Sciences : BES·Ai Jing MaYan Lin Zhao

❮ Previous
Next ❯

Citations

Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Yan ShaoCheng Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Gel Image Analysis System
SPSS
Mega5

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
K-S ChenG-C Xiong
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
D García de ViedmaINDAL-TB working group
The Journal of Infectious Diseases
Richard E Chaisson, Gavin J Churchyard
© 2021 Meta ULC. All rights reserved