PMID: 6403948Apr 1, 1983Paper

Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block

Proceedings of the National Academy of Sciences of the United States of America
A Yazaki, S Ohno

Abstract

Within the published 2,168-base-long mouse C mu gene of Ig heavy chain consisting of four coding and four noncoding segments, 2 base decamers, 8 nonomers, and 39 octamers recurred. Recurring base heptamers (about 100) and hexamers (about 350) were simply too numerous to merit individual identification. In spite of extensive overlaps between these recurring base decamers to hexamers, they occupied nearly the entire length of mouse Ig C mu gene. As with other genes of the beta-sheet-forming beta 2-microglobulin family, the Ig C mu gene (flanking and intervening noncoding sequences included) is not a unique sequence but rather it is degenerate repeats of the 45-base-long primordial building-block sequence uniquely its own. This primordial building block must originally have specified the 15-amino-acid-residue-long primordial arm of beta-sheet-forming loops, the characteristics of the beta 2-microglobulin family of polypeptides.

References

May 14, 1982·Science·A F Williams, J Gagnon
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S OhnoR B Wallace
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A A ReyesR B Wallace
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S OhnoR B Wallace
Aug 20, 1982·Science·R J Douthart, F H Norris

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Citations

Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Ohno, J T Epplen
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·I HakimG Rechavi

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