PMID: 6991375Feb 1, 1980Paper

Recurrence of duodenal ulcer pain after treatment with cimetidine for four and eight weeks

Gut
S J RuneH R Wulff

Abstract

This double-blind controlled trial compares the relapse rate in 19 duodenal ulcer patients who received cimetidine for eight weeks with that in 19 patients who received cimetidine for four weeks and inactive tablets for four weeks. Only patients who became symptom-free during the initial four weeks' treatment with cimetidine were included. The median period of remission after withdrawal of cimetidine was 50 days in patients treated with cimetidine for eight weeks and 76 days in patients treated with cimetidine for four weeks (P greater than 0.10). Six months after withdrawal of cimetidine 15 relapses had occurred in both groups. It is concluded that patients who become symptom-free during four weeks' cimetidine treatment do not benefit by continuation of treatment for another four weeks.

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·E Gudmand-HöyerH R Wulff
Apr 29, 1978·British Medical Journal·E Gudmand-HøyerH R Wulff

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Citations

Apr 28, 1993·European Journal of Pharmacology·M ShibataH Ohnishi
Jun 1, 1981·Klinichna khirurhiia·A A Shalimov, V F Saenko
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·K Lauritsen, E Christensen
Nov 1, 1985·Journal of Clinical Pharmacology·N CharletR J Wills
Sep 28, 1987·The American Journal of Medicine·M RodrigoJ L Segu
Jun 1, 1985·Australian and New Zealand Journal of Medicine·A J McLeanF J Dudley
Nov 27, 1982·British Medical Journal·M J Langman
May 9, 1981·British Medical Journal
Jan 1, 1988·Acta Medica Scandinavica·T Gjørup, O J Hartling
Jan 1, 1993·Alimentary Pharmacology & Therapeutics·G DobrillaS Amplatz

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