PMID: 8590144Oct 1, 1995Paper

Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection

European Journal of Gastroenterology & Hepatology
S MiehlkeE Bästlein

Abstract

Chronic Helicobacter pylori-associated gastritis is now widely accepted as one of the most important pathogenic factors in duodenal ulcer disease. However, little is known about for how long patients remain free of duodenal ulcer relapses after H. pylori infection has been cured. In the present study, we investigated remission time during a 5-year follow-up period after anti-H. pylori treatment. The patients were randomly allocated to treatment with either a combination of 3 x 600 mg bismuth subsalicylate and 2 x 1000 mg amoxycillin or 3 x 600 mg bismuth subsalicylate monotherapy. Endoscopy, including histological and microbiological examination of biopsies, was performed 4 weeks after termination of treatment and after 1 and 2 years. During the third, fourth and fifth years of the follow-up period, patients were monitored twice a year for symptoms compatible with ulcer relapse and for their use of anti-ulcer medication. Endoscopic and histological examinations were carried out whenever symptoms occurred. Of 56 evaluated patients, 47 showed healing of ulcers after bismuth subsalicylate plus amoxycillin compared with 44 of 57 after bismuth subsalicylate monotherapy. H. pylori infection was cured in 52% (29 of 56) of the patients...Continue Reading

Citations

Aug 13, 2002·European Journal of Gastroenterology & Hepatology·Javier P GisbertJosé María Pajares
Aug 1, 1997·Journal of Gastroenterology and Hepatology·J Q Huang, R H Hunt
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Jian Jun ZhaoYan Li
Oct 16, 1999·Scandinavian Journal of Gastroenterology·S Olafsson, A Berstad
Mar 18, 2000·Journal of Chemotherapy·G MaconiG Bianchi Porro
Sep 1, 2005·The American Journal of Gastroenterology·Javier P Gisbert
Dec 29, 1998·Scandinavian Journal of Gastroenterology·J P GisbertA García-Plaza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.