Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?

Pediatric Blood & Cancer
Melina HeinemannUta Dirksen

Abstract

The Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse. A retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death. In the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P < 0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP expe...Continue Reading

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Citations

Feb 13, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·B VaarwerkM A Grootenhuis
Jul 2, 2020·OncoTargets and Therapy·Deepam PushpamBivas Biswas
Jul 7, 2018·Nature Reviews. Disease Primers·Thomas G P GrünewaldUta Dirksen
Nov 13, 2020·Pediatric Blood & Cancer·Melina HeinemannUta Dirksen
Jan 10, 2020·Journal of Adolescent and Young Adult Oncology·Thomas CashHoward M Katzenstein
May 1, 2021·Journal of Clinical Medicine·Stefan K ZöllnerUta Dirksen

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