Abstract
The clinical and renal biopsy findings in 3 patients with recurrent focal and segmental glomerulosclerosis (FSG) are reported, as well as the results of a survey among 17 European centers totaling 27 kidney-transplanted children with FSG. From these 27 patients, 10 had recurrent FSG. The duration of the original disease was less than 3 years in 9 of them. In contrast, this rapid progression of the disease was observed in only 7 of 17 patients in the group without recurrences. Heavy proteinuria was noted within the 1st day, or week, in all but 2 patients where it was detected at 3 and 7 weeks. All developed the nephrotic syndrome. From the 10 kidneys (mostly from cadaver donors) which functioned for more than 1 month, 5 were lost 2--24 months after transplantation because of recurrence (3 patients) or infection (2 patients). It appears that the risk of recurrence can best be predicted by the duration of the original disease: 50% or more if the duration was short (less than 3 years), and only 10--20% when the duration was longer.
Citations
Jan 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P SenggutuvanG Koffman
Jan 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M R First
Jul 1, 1988·Indian Journal of Pediatrics·D B Gradus, R N Fine
Jun 1, 1994·Transplant Immunology·A R Morley
Dec 21, 2002·Transplantation Proceedings·C PonticelliA Tarantino
Mar 20, 1999·Transplantation Proceedings·S J KimH S Lee
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E L Ramos, C C Tisher
Mar 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetE J Lewis
Jul 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D GlicklichR A Weiss
Aug 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M BrensilverR McCabe
May 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A SchwarzF Keller
Jan 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J S CheighA L Rubin
Mar 1, 1984·Mayo Clinic Proceedings·V E TorresS Sterioff
Sep 1, 1982·Kidney International·E J Lewis
Apr 1, 1986·Kidney International·J J WeeningJ D Elema
Apr 1, 1988·Kidney International·D L Mendrick, H G Rennke
Dec 21, 2010·Transplantation Proceedings·H K KfouryM Arafah
Apr 1, 1992·The American Journal of Medicine·M ArteroF Vincenti
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M B AndresdottirJ F Wetzels
May 1, 2001·Pediatric Transplantation·S J KimY Choi
May 1, 2001·Pediatric Transplantation·J M Sorof, J Samuels
Apr 2, 1984·Klinische Wochenschrift·E P Leumann, J Briner
Oct 15, 2018·Transplantation Proceedings·S JungJ Song
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Reem H RaafatSteven C Diven