Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation.

Scientific Reports
Bo YuanShuo Song

Abstract

Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients is receiving more attention. Herein we report a cohort study on the follow-up of 182 recovered patients under medical isolation observation. Twenty (10.99%) patients out of the 182 were detected to be SARS-CoV-2 RNA positive (re-positives), although none showed any clinical symptomatic recurrence, indicating that COVID-19 responds well to treatment. Patients aged under 18 years had higher re-positive rates than average, and none of the severely ill patients re-tested positive. There were no significant differences in sex between re-positives and non-re-positives. Notably, most of the re-positives turned negative in the following tests, and all of them carried antibodies against SARS-CoV-2. This indicates that they might not be infectious, although it is still important to perform regular SARS-CoV-2 RNA testing and follow-up for assessment of infectivity. The findings of this study provide information for improving the management of recovered patients, and for differentiating the follow-up of recovered patients with different risk levels.

References

Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 28, 2020·JAMA : the Journal of the American Medical Association·Lan LanHaibo Xu
Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungUNKNOWN Singapore 2019 Novel Coronavirus Outbreak Research Team
Mar 13, 2020·Travel Medicine and Infectious Disease·Ye-Min QuHai-Yan Cong
Mar 23, 2020·The Lancet. Gastroenterology & Hepatology·Yongjian WuXi Huang
Mar 29, 2020·The European Respiratory Journal·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Mar 30, 2020·MedRxiv : the Preprint Server for Health Sciences·Zheng Zh AnZheng Zhang

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Citations

Sep 24, 2020·Reviews in Medical Virology·Eamon O MurchuPatricia Harrington
Aug 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin Kai-Wang ToKwok-Yung Yuen
Oct 11, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Anna GidariDaniela Francisci
Oct 29, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Thi Loi DaoPhilippe Gautret
Oct 23, 2020·Disaster Medicine and Public Health Preparedness·Yanfei He, Yu-Chao Dong
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yujie BaoYing Wang
Feb 6, 2021·ACS Sensors·Guoqiang Liu, James F Rusling
Dec 9, 2020·Journal of Medical Virology·Robin L KlingenMirko Trilling
Mar 6, 2021·BMJ Case Reports·Sook Yin LohMartin Walshaw
Mar 2, 2021·Frontiers in Cellular and Infection Microbiology·Shamila D AlipoorIan M Adcock
Feb 10, 2021·The Journal of Clinical Investigation·Zhen HuangTony Y Hu
Apr 4, 2021·Viruses·Szilárd VáncsaPéter Hegyi
May 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Liguo ZhangRudolf Jaenisch
May 13, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jorge L SepulvedaAntonia R Sepulveda
Jun 1, 2021·Journal, Genetic Engineering & Biotechnology·Antoine Fakhry AbdelMassihBiagio Castaldi
May 28, 2021·Journal of Family Medicine and Primary Care·Tanisha VoraHardik D Desai
Jul 2, 2021·Clinical Case Reports·Shahram AhmadianHossein Samadi Kafil
Aug 3, 2021·Medical Journal, Armed Forces India·Arun Kumar YadavSudhir Dubey
Aug 16, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lijun LiangJie Wu

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Software Mentioned

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