Recurrence of primary sclerosing cholangitis in patients after liver transplantation

Transplantation Proceedings
U Ołdakowska-JedynakL Paczek

Abstract

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease that progresses to end-stage liver disease. There are several specific problems related to the posttransplantation period in these patients. The aim of this study was to analyze a single center experience with 17 orthotopic liver transplantations (OLT) due to PSC. Seventeen patients were included (10 men, 7 women). Actuarial patient and graft survival rates and the incidence of recurrent sclerosing cholangitis were determined at 1, 5, and 7 years. Fifteen patients received single grafts, whereas two patients required retransplants. Patients received either cyclosporine (n = 7) or tacrolimus (n = 10) based immunosuppression. The 1-, 5-, and 7-year patient survival rates were 80%, 60%, and 60%, respectively, whereas the graft survival rates were 88%, 65%, and 65%, respectively. Two patients had cholangiocarcinomas (CCA) diagnosed during OLT; both recurred within 6 months and had a fatal outcome. Two patients (12%) developed recurrent sclerosing cholangitis, as assessed by liver histology and imaging of biliary tree. Liver transplantation provides good patient and graft survival rates in cases affected with PSC. CCA is associated with poor recipient survival. Re...Continue Reading

References

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Citations

Jan 10, 2012·World Journal of Gastroenterology : WJG·Bjarte FosbyEspen Melum
May 13, 2008·Journal of the American College of Surgeons·Timothy M PawlikJohn L Cameron
Mar 29, 2014·Interventional Medicine & Applied Science·Fanni GelleyBalázs Nemes
Jan 16, 2014·Autoimmunity Reviews·Kidist K Yimam, Christopher L Bowlus
May 31, 2014·Inflammatory Bowel Diseases·Andres J YarurCynthia Levy
Oct 13, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Manjushree GautamVijayan Balan
Feb 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Evangelos CholongitasAndrew K Burroughs

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