Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study

Annals of the Rheumatic Diseases
E DernisM Breban

Abstract

To examine the recurrence of manifestations belonging to the spectrum of spondylarthropathy (SpA) in first-degree relatives of patients with SpA, and to estimate the recurrence risk ratio. Parents and siblings of consecutive SpA probands have been thoroughly investigated, including clinical data collection, pelvic x ray and human leukocyte antigen (HLA)-B27 status determination. The diagnosis of SpA was made according to European Spondylarthropathy Study Group and/or the Amor criteria. The recurrence risk ratio lambda(1), which gives an estimate of the weight of genetic factors, was calculated as the ratio of the recurrence risk of SpA in first-degree relatives compared with the population prevalence of SpA. The lambda(non-HLA) was obtained by similar calculations restricted to HLA-B27+ individuals. Most manifestations of SpA were more frequent among the 157 HLA-B27+ relatives of 83 probands than among their 111 HLA-B27- relatives. A diagnosis of SpA was made in 50 relatives of 31 (37%) probands. Recurrence was very similar between parents and siblings, without gender difference, resulting in overall recurrence risk of 12% in first-degree relatives and of 22.7% in HLA-B27+ relatives. The lambda(1) value was 40 and the lambda(no...Continue Reading

Citations

Dec 29, 2011·Clinical Rheumatology·Hellen M S de CarvalhoUNKNOWN Brazilian Registry on Spondyloarthritis
Dec 27, 2013·Rheumatology·Jacqueline E Paramarta, Dominique Baeten
Mar 26, 2014·Arthritis & Rheumatology·Maxime BrebanGilles Chiocchia
Apr 24, 2015·Current Rheumatology Reports·Maxime BrebanHenri-Jean Garchon
Nov 30, 2013·Clinical Rheumatology·Abtin ShahlaeeAhmad Reza Jamshidi
Jul 28, 2016·Annals of the Rheumatic Diseases·Félicie CostantinoHenri-Jean Garchon
Jan 19, 2018·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Amal Akassou, Youssef Bakri
May 27, 2020·Current Opinion in Rheumatology·Maedeh AshrafiMichael H Weisman
Jan 9, 2019·Frontiers in Immunology·Félicie CostantinoHenri-Jean Garchon
Oct 8, 2020·Journal of Personalized Medicine·Roberto Díaz-PeñaAlejandro Lucia
Jan 16, 2021·Seminars in Immunopathology·Maxime BrebanLuiza M Araujo
Jun 22, 2021·Frontiers in Genetics·Félicie CostantinoMaxime Breban

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