Recurrence Patterns After Anatomic or Parenchyma-Sparing Liver Resection for Hepatocarcinoma in a Western Population of Cirrhotic Patients

Annals of Surgical Oncology
Simone FamularoLuciano De Carlis

Abstract

The optimal surgical strategy to lessen the risk of hepatocarcinoma (HCC) recurrence is debated. This study aimed to investigate the role of anatomic resection (AR) and parenchyma-sparing resection (PSR) in HCC recurrence patterns. The study analyzed 384 cirrhotic patients with a first diagnosis of HCC. Of these patients, 142 underwent AR, and 242 underwent PSR. The two groups were unbalanced at the univariate analysis. To minimize this bias, a 1:1 propensity score-matching analysis (PSA) was used. Disease-free survival (DFS) curves were analyzed by the Kaplan-Maier method. The PSA allowed pairing of 200 patients (100 for AR and 100 for PSR). In this study, 59 patients (62.8%) had recurrence after AR compared with 58 patients (63.7%) after PSR (p = 0.891). The rates of local recurrence were respectively 15.3% and 15.5% (p = 0.968). When microvascular invasion was considered, the median DFS was 10.7 months for AR and 9.4 months for PSR (p = 0.607). In comparisons of AR and PSR, DFS did not differ significantly between subgroups with high histologic grading (p = 0.520), multiple nodules (p = 0.307), and Child-Pugh B (p = 0.679). Excision of the anatomic segment did not seem to reduce the rate of relapse or recurrence patterns sig...Continue Reading

References

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Citations

Feb 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Simone FamularoLuciano De Carlis
Jan 23, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simone FamularoFabrizio Romano
Oct 23, 2019·International Journal of Molecular Medicine·Dan-Hong HuangLi-Zhen Liu
Jun 28, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Diamantis I TsilimigrasTimothy M Pawlik
Mar 23, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simone FamularoUNKNOWN HE.RC.O.LE.S. Group
Nov 5, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simone FamularoUNKNOWN HE.RC.O.LE.S. Group
Jan 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simone FamularoLuciano De Carlis

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