Recurrence risks for trisomies 13, 18, and 21

American Journal of Medical Genetics. Part a
E de SouzaJoan K Morris

Abstract

The objective was to establish whether the risk of trisomies 13, 18, and 21 (Patau, Edwards, and Down syndrome, respectively) in a subsequent pregnancy is raised for women who have had a previous pregnancy with trisomy 13, 18, or 21. Birth defect register data were used to investigate this issue. Pregnancy data from three Australian population-based birth defect registers contained 5,906 women with a previous trisomy 13, 18, or 21 pregnancy in whom there were 3,713 subsequent pregnancies, 75 of which were trisomic. Relative risk of subsequent trisomy at 15 weeks gestation was estimated by comparing the observed number of subsequent trisomies with the expected number of subsequent trisomies based on maternal age-related risk. There was evidence of increased risk of the same trisomy subsequent to a previous pregnancy with trisomy 13 or 18 (RR = 3.8 (1.5, 7.9)), the increase in risk being greater for women aged under 35 at the previous trisomic pregnancy (RR = 7.8 (2.1, 20.2)). There was also evidence of increased risk of trisomy 21 subsequent to previous trisomy 21 (RR = 2.2 (1.6, 2.9)), again higher in women under 35 at previous affected pregnancy (RR = 3.5 (2.1, 5.5)). There was a suggestion that the risk of a different trisomy...Continue Reading

References

Aug 1, 1995·Journal of Paediatrics and Child Health·M KilkennyJ Lumley
Apr 12, 2002·Journal of Medical Screening·J K MorrisE Alberman
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Anders BojesenClaus Højbjerg Gravholt
Sep 16, 2004·Journal of Paediatrics and Child Health·M RileyJ Halliday
Apr 25, 2006·Prenatal Diagnosis·George M SavvaEva Alberman
Dec 25, 2007·The Journal of Pediatrics·Veronica R CollinsJane L Halliday
Mar 26, 2008·American Journal of Medical Genetics. Part a·Joan K Morris, George M Savva
Sep 20, 2008·Molecular Cytogenetics·Maj A HulténErik Iwarsson

❮ Previous
Next ❯

Citations

Apr 13, 2012·American Journal of Medical Genetics. Part a·Eva AlbermanJoan K Morris
Feb 2, 2011·Cytogenetic and Genome Research·C TempladoA Estop
Oct 24, 2012·Orphanet Journal of Rare Diseases·Anna Cereda, John C Carey
Feb 25, 2010·Molecular Cytogenetics·Maj A HulténErik Iwarsson
Jan 5, 2016·Seminars in Perinatology·Mary E Norton, Britton D Rink
Apr 24, 2012·Fertility and Sterility·Nasser Al-AsmarCarmen Rubio
Feb 26, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A Borrell, I Stergiotou
Feb 22, 2012·Congenital Anomalies·Hiroki KurahashiTamae Ohye
Jan 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aliza AmielTal Biron-Shental
Nov 14, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M TurgalM S Beksac
Feb 6, 2019·Biology of Reproduction·Carmen RubioCarlos Simón
Mar 5, 2016·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—ObstetricsUNKNOWN Society for Maternal–Fetal Medicine
Sep 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maribel GrandeAntoni Borrell
Aug 25, 2018·Molecular Cytogenetics·Xiangyu ZhuYali Hu
Sep 1, 2010·Personalized Medicine·Peter Tolias, Gokce A Toruner
Feb 9, 2018·Obstetrics and Gynecology·Line Elmerdahl FrederiksenCharlotte Kvist Ekelund
Feb 6, 2020·Journal of Assisted Reproduction and Genetics·T V NikitinaI N Lebedev
Jul 22, 2021·Molecular Genetics & Genomic Medicine·Verónica Fabiola Morán-BarrosoFernando Fernández-Ramírez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.