PMID: 9541099Apr 16, 1998Paper

Recurrence risks in mental retardation

Journal of Medical Genetics
Y J Crow, J L Tolmie

Abstract

Despite improvements in diagnostic techniques and progress made in mapping genes associated with syndromal mental handicap, the estimation of recurrence risks in non-syndromal mental retardation is still dependent on empirical data. Unfortunately, few studies are available to guide the clinician and their results differ significantly. For example, recurrence risks to all sibs of a male index patient with severe mental retardation vary between 3.5% and 14% in commonly quoted series. The present review highlights the problems involved in interpreting the previous work in this area and discusses the definition of mental retardation according to the degree of severity, phenotype, and its pattern of inheritance. In planning future studies, an appreciation of these issues should allow us to derive accurate and comparable risk figures for use in counselling affected subjects and their families.

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Citations

Aug 10, 2006·Journal of Autism and Developmental Disorders·Lonnie ZwaigenbaumMarian Sigman
Aug 25, 2005·Journal of Medical Genetics·F L Raymond
Sep 17, 2011·Genome Biology·Christian GilissenJoris A Veltman
Oct 4, 2005·Indian Journal of Medical Sciences·A S AhujaM J Owen
Nov 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ye WuTao Wang
Apr 7, 2009·Journal of Health Economics·Dean A RegierCarlo A Marra
Apr 8, 2011·Clinical Genetics·J S CollinsR E Stevenson
Apr 20, 2010·American Journal of Human Genetics·Dean A RegierCarlo A Marra
Jul 14, 2001·American Journal of Medical Genetics·D Toniolo
Feb 26, 2004·American Journal of Medical Genetics. Part a·Carmen EsmerVictoria Del Castillo
Aug 21, 2004·European Journal of Human Genetics : EJHG·Jean-Louis Mandel, Jamel Chelly
Jul 1, 1999·Plant Disease·B SalasP B Schwarz
Dec 18, 2004·Journal of Genetic Counseling·Helen Levy, Wendy Packman
Jul 1, 2003·Paediatrics & Child Health·Jean-François LemayA Micheil Innes
Feb 15, 2000·Genome Research·J Gécz, J Mulley

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