Recurrent Abdominal Pain in Children: Summary Evidence From 3 Systematic Reviews of Treatment Effectiveness

Journal of Pediatric Gastroenterology and Nutrition
Rebecca A AbbottS Logan

Abstract

Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. We carried out a systematic review of randomised controlled trials (RCTs) in eleven databases and 2 trials registries from inception to June 2016. An update search was run in November 2017. All screening was performed by 2 independent reviewers. Included studies were appraised using the Cochrane risk of bias tool and the evidence assessed using GRADE. We included any dietary, pharmacological or psychosocial intervention for RAP, defined by Apley or an abdominal pain-related functional gastrointestinal disorder, as defined by the Rome III criteria, in children and adolescents. We included 55 RCTs, involving 3572 children with RAP (21 dietary, 15 pharmacological, 19 psychosocial, and 1 multiarm). We found probiotic diets, cognitive-behavioural therapy (CBT) and hypnotherapy were reported to reduce pain in the short-term and there is some evidence of medium term effectiveness. There was insufficient evidence of effectiveness for all other dietary interventions and psychosocial therapies. There was no robust evidence of effectiveness for pharmacological interventions. Overall the evidence bas...Continue Reading

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Citations

Feb 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yan DongJiande D Z Chen
Mar 30, 2020·The American Journal of Gastroenterology·Negin BadihianHossein Saneian
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Dec 7, 2018·Nutrients·Anna PärttyMarko Kalliomäki
Jun 3, 2021·Children·Lindsay T IvesNancy L Zucker
Nov 7, 2020·Nature Reviews. Disease Primers·Nikhil ThaparPaul Enck

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Methods Mentioned

BETA
RAP
cognitive-behavioural therapy

Software Mentioned

Cochrane
Review Manager
Grading of Recommendations Assessment Development and Evaluati...

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