Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema

Internal Medicine
Keiichi IwanamiTomohiro Morio

Abstract

A diagnosis of hereditary angioedema is usually made with recurrent episodes of swelling of the subcutaneous tissue with a family history. We herein report a case in which recurrent acute abdomen was the main manifestation of hereditary angioedema. A 45-year-old womon presented with a 10-year history of recurrent severe abdominal pain. Abdominal computed tomography revealed remarkable submucosal edema of the ileum. A blood examination revealed grossly reduced complement C4 and CH50 with deficiency of C1-inhibitor. Genetic testing revealed a heterozygous nonsense mutation of the SERPING1 gene, and a diagnosis of hereditary angioedema was made. Hereditary angioedema should be listed as a differential diagnosis of recurrent acute abdomen.

References

May 1, 1976·Annals of Internal Medicine·M M FrankJ P Atkinson
Feb 9, 2006·The American Journal of Gastroenterology·Konrad BorkJochen Hardt
Feb 24, 2006·The American Journal of Medicine·Konrad BorkJochen Hardt
Sep 5, 2008·The New England Journal of Medicine·Bruce L Zuraw
Jul 17, 2009·The New England Journal of Medicine·De-Feng Huang, Wei-Sheng Chen
Jan 4, 2013·The World Allergy Organization Journal·Timothy CraigMarcus Maurer

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Citations

Oct 9, 2019·The British Journal of Oral & Maxillofacial Surgery·T Uzun
Jan 2, 2022·BMJ Case Reports·Mayven Tien Li SiowPaul A Blaker

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Methods Mentioned

BETA
hormone-replacement therapy

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