Recurrent acute hepatitis associated with use of cetirizine

The Annals of Pharmacotherapy
Maurizio PompiliGian Ludovico Rapaccini

Abstract

To describe a case of recurrent acute hepatitis related to the use of cetirizine, a selective histamine(1)-receptor antagonist approved for the treatment of common allergic diseases. A 26-year-old man was hospitalized with a week-long history of weakness, nausea, anorexia, and hyperchromic urine, which had developed after 6 days of therapy with oral cetirizine 10 mg/day for allergic rhinitis. Admission laboratory testing revealed evidence of acute hepatitis and seropositivity for liver-kidney microsome antibodies. Liver biopsy findings of diffuse portal tract and lobular inflammation with a prominent eosinophilic infiltrate were consistent with drug-related hepatitis. The patient was discharged after one week of treatment with tocopherol and glutathione. Three months after discharge, transaminase levels were normal. At 6 months, seropositivity for liver-kidney microsome antibodies was still present, but considerably less intense. The patient had suffered 2 previous episodes of "acute hepatitis of unknown origin," and both had occurred after cetirizine use. Use of the Naranjo probability scale indicated cetirizine as the probable cause of acute hepatitis, and the positivity for liver-kidney microsome antibodies is suggestive of ...Continue Reading

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Citations

Jan 22, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Carmen FerrajoloUNKNOWN EU-ADR consortium
Sep 30, 2008·Drug Metabolism Reviews·Young-Mi AhSang Geon Kim
Dec 15, 2010·Medicina clínica·José María Prieto de PaulaAntonio Ginés Santiago
May 22, 2009·Gastroenterología y hepatología·Santiago José Rodríguez-GómezMaría Isabel Martín-Arribas
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Sep 1, 2016·Gastroenterology Report·Adil CoskunVahit Yukselen

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Methods Mentioned

BETA
biopsy

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