Recurrent acute transverse myelopathy: association with antiphospholipid antibody syndrome

Indian Journal of Pediatrics
Vijaya ShaharaoVrajesh P Udani

Abstract

A seven-year-old boy presented with a second episode of acute transverse myelopathy. The first episode had responded dramatically to methylprednisolone. The manifestations of the second episode did not respond to methylprednisolone or IVIG. He showed persistently raised levels of antiphospholipid antibodies in the serum. Primary conditions like collagen vascular diseases, malignancy, exposure to drugs and HIV infection, which are known to be associated with the raised titers of these antibodies were ruled out clinically and by investigations. Recurrent transverse myelopathy is a rare event in childhood and reports of its association with Antiphospholipid Antibody Syndrome (APLAS) are scanty. The etiological role for these antibodies remains to be established. However, once the diagnosis is established, it may be prudent to treat the condition with agents and procedures to bring about a decrease in their titers. Long-term therapy to prevent thromboembolic complications of APLAS may also be instituted.

References

May 1, 1991·Neurology·D S TippettH S Panitch
Jun 1, 1986·Journal of Neurology·M Yamamoto
Aug 1, 1996·Journal of the Neurological Sciences·M MatsuiY Kuroda
Oct 1, 1996·Lupus·S R Levine, R L Brey
Nov 14, 1998·Lupus·W A WilsonA E Gharavi

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Citations

Sep 16, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C G KatsiariP P Sfikakis
Mar 29, 2008·Postgraduate Medical Journal·A Theodoridou, L Settas
Oct 15, 2009·Rheumatology International·Briele KeisermanHenrique Luiz Staub
Jul 22, 2005·Lancet Neurology·Amanda CoxAlastair Compston
Apr 27, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Régis LevasseurMarie Christine de Vernejoul
Dec 14, 2018·Frontiers in Pediatrics·Chris Wincup, Yiannis Ioannou

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