Recurrent and Fixed Neutrophilic Dermatosis Associated With Dasatinib

Journal of Cutaneous Medicine and Surgery
Joel C BergmanPeter R Hull

Abstract

Dasatinib is a tyrosine kinase inhibitor indicated for the treatment of chronic myeloid leukemia (CML). Skin rashes are common, occurring in about a quarter of patients treated, and are generally mild. The commonest rash is a keratosis pilaris-like eruption. A neutrophilic dermatosis has rarely been reported. We report a patient whose CML was successfully treated with dasatinib and who several years later developed episodes of a neutrophilic dermatosis recurring at the same sites. This report extends the clinical spectrum of neutrophilic dermatoses to include dasatinib-induced recurrent and fixed erythematous plaques.

References

Aug 8, 2001·The Australasian Journal of Dermatology·K L Agnew, G F Oliver
Sep 27, 2003·The British Journal of Dermatology·S UgurelS Goerdt
Mar 23, 2005·Archives of Dermatology·Sanjay J AyirookuzhiGlenn Mills
Jun 16, 2006·The New England Journal of Medicine·Sarit AssoulineCarlo Gambacorti-Passerini
Nov 22, 2008·European Journal of Clinical Investigation·K J AichbergerP Valent
Dec 18, 2012·European Journal of Haematology·Aaron M DruckerMario E Lacouture
May 17, 2013·JAMA Dermatology·Sara SamimiEllen J Kim
Jan 31, 2016·The American Journal of Dermatopathology·Sanaz Ainechi, John Andrew Carlson

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Citations

Apr 2, 2019·The Journal of Dermatology·Tomoko MatsudaHiroyuki Okamoto

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Methods Mentioned

BETA
biopsies
biopsy

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