Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study

Cancer Medicine
Lei QinSzu-Yuan Wu

Abstract

Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan. We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Patients in the non-RAS cohort were matched to case study patients at a 1:1 ratio through frequency matching. All participants were followed up for at least 5 years, and those who received cancer diagnoses during follow-up were identified. Among 52 307 patients with and 52 304 patients without RAS, the combined hazard ratio (HR) of all subsequent cancer cases was 1.3 (95% confidence interval [CI]: 1.25-1.35, P = 0). RAS diagnosis was associated with risk for cancers of the head and neck (aHR = 2, 95% CI: 1.8-2.3), colon (aHR = 1.2, 95% CI: 1.1-1.4), liver (aHR = 1.1, 95% CI: 1-1.3), pancreas (aHR = 1.4, 95% CI: 1.1-1.7), skin (aHR = 1.4, 95% CI: 1.2-1.7), breast (aHR = 1.2, 95% CI: 1.1-1.4), and prostate (aHR = 1.5, 95% CI: 1.3-1.8), as well as hematologic cancers (aHR = 1.6, 95% CI: 1.3-1.9). A higher risk was observed for male patients (aHR = 1.35, 95% CI: 1.28-1.42) tha...Continue Reading

References

Nov 1, 1991·American Journal of Epidemiology·J S GroveG N Stemmermann
Jun 1, 1991·Annals of the Rheumatic Diseases·N ArberA Weinberger
Jun 1, 1994·The Journal of Dermatology·R ItohM Mizoguchi
Jun 9, 1998·Japanese Journal of Cancer Research : Gann·C Y Yang, Y L Hsieh
Oct 30, 1998·Journal of Hypertension·A RosengrenH Wedel
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 24, 2001·Journal of the American College of Cardiology·J C ChambersJ S Kooner
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jun 27, 2001·Rheumatology·A GülG Saruhan-Direskeneli
Jul 18, 2001·Biological & Pharmaceutical Bulletin·S YamashitaS Toyoshima
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuji YamanishiGary S Firestein
Oct 9, 2002·Scandinavian Journal of Rheumatology·Kamel HamzaouiKhaled Ayed
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Oct 7, 2004·The Lancet Oncology·Edna Maria Vissoci ReicheHelena Kaminami Morimoto
Oct 21, 2004·The Journal of the Royal Society for the Promotion of Health·Sarah Payne
Mar 2, 2005·Rheumatology International·Meral KayikçioğluEker Doganavsargil
Jun 4, 2005·Arthritis and Rheumatism·Jumana KarasnehJane Worthington
Jun 22, 2005·Survey of Ophthalmology·Cem Evereklioglu
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Jan 26, 2007·Clinical and Experimental Dermatology·E B BaskanS Tunali
May 15, 2007·Mediators of Inflammation·Nelson L RhodusFrank Ondrey
Sep 14, 2007·The British Journal of Oral & Maxillofacial Surgery·Crispian Scully, Stephen Porter
Mar 14, 2008·Clinical and Experimental Immunology·K NaraN Suzuki
May 29, 2009·Australian Dental Journal·L M Abetz, N W Savage
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Otis W Brawley
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 5, 2011·The Journal of Allergy and Clinical Immunology·Guillaume GeriDavid Saadoun
Jan 4, 2012·Histopathology·Karen S Sfanos, Angelo M De Marzo
May 10, 2012·Clinical Epidemiology·Daniel J NivenKevin B Laupland
Jun 15, 2012·Thrombosis Research·Andrew D Blann

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