Recurrent aplastic anemia with donor-type aplasia: A rare occurrence in the Indian subcontinent.

Journal of Postgraduate Medicine
A MajumderV Kumar

Abstract

Donor-type aplasia (DTA) is a condition where an individual continues to be aplastic even after a successful engraftment of a hematopoeitic stem cell transplant with a majority of donor type cells in the bone marrow. This entity has been seen with varying frequency around the world, especially in Southeast Asia. However, its incidence in the Indian subcontinent remains fairly low. Here is a case of a 17-year-old child with DTA who had a 89% population of donor cells after a successful transplant and presented with recurrent severe aplastic anemia later. The patient eventually succumbed to his condition before a second transplant could be performed. The awareness about the seriousness of this relatively rare condition, therefore, needs to be emphasized.

References

Feb 23, 1999·British Journal of Haematology·M EapenN K Ramsay
Dec 30, 2017·British Journal of Haematology·Sujith SamarasingheRob Wynn
Nov 17, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Abigail ShawUNKNOWN Aplastic Anaemia Working Party of the European Society for Blood and Marrow Transplantation

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