PMID: 3214653Jul 1, 1988Paper

Recurrent bone regeneration in titanium implants. Experimental model for determining the healing capacity of bone using quantitative microradiography

Biomaterials
P Kälebo, M G Jacobsson

Abstract

An experimental technique for quantitative assessment of bone repair was tested. The recurrent regeneration capacity of cortical bone was analyzed in consecutive 3 wk periods, using an osseointegrated titanium implant, the Bone Harvest Chamber (BHC), in the proximal tibial metaphysis of the rabbit. The BHC is a divisible implant penetrated by a canal into which newly formed bone tissue will grow during a 3 wk healing period. The newly formed bone tissue may easily be collected (harvested) without the animal being killed. After 3 wk, bone tissue can again be harvested, in principle, indefinitely. Intact harvested specimens were quantified by microradiography-videodensitometry, yielding a total specimen mass in mg aluminium equivalent. This unit correlated very well to a specimen dry weight (r = 0.996) and an average mineralized bone density (r = 0.937). The specimens were also examined by correlative histology. Three weeks after implant insertion, the chambers had become integrated in the bone tissue but the average bone mass varied widely, influenced by the surgical insertion trauma. Six weeks after insertion, the greatest average bone mass was found, indicating an intense ongoing osseointegration. The amount of bone regenerate...Continue Reading

References

Aug 1, 1978·Clinical Otolaryngology and Allied Sciences·A Tjellstrom
Aug 1, 1979·Acta Orthopaedica Scandinavica·T Sekiguchi, T Hirayama
Jan 1, 1987·Acta Oncologica·P KäleboI Turesson
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E BarthB Saethren
Jul 1, 1985·Calcified Tissue International·G MazzuoliC Valtorta
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H AroA J Aho
Jan 1, 1969·Scandinavian Journal of Plastic and Reconstructive Surgery·P I BrånemarkA Ohlsson
Sep 1, 1983·Calcified Tissue International·A Rubinacci, L Tessari
Jan 1, 1984·Archives of Orthopaedic and Trauma Surgery·T Albrektsson
Jun 1, 1984·Acta Orthopaedica Scandinavica·H RønningenN Langeland
Jan 1, 1980·Scandinavian Journal of Plastic and Reconstructive Surgery·T Albrektsson
Jan 1, 1981·Journal of Biomedical Materials Research·S M ColellaD M Spengler
Aug 1, 1956·The Journal of Bone and Joint Surgery. British Volume·M OWEN
Jan 7, 2005·The Journal of Bone and Joint Surgery. American Volume·Pankaj Sharma, Nicola Maffulli

❮ Previous
Next ❯

Citations

Sep 1, 1990·Journal of Biomedical Materials Research·J M SpivakH Alexander
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouK W Ng
Jan 1, 1993·Archives of Orthopaedic and Trauma Surgery·F BuchP Kälebo
Jun 1, 1994·Biomaterials·J R MariolaniA C de Arruda
Sep 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J L RicciH Alexander
May 26, 1999·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J AceroM L Somacarrera
Oct 1, 1989·The British Journal of Radiology·P Kälebo, K G Strid
Mar 13, 2019·Journal of Audiology & Otology·Tae Hoon KongYoung Joon Seo
Dec 1, 1993·Acta Orthopaedica Scandinavica·S GoodmanL Lidgren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved