Recurrent corneal perforation and acute calcareous corneal degeneration in chronic graft-versus-host disease.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Po-Ting YehFung-Rong Hu

Abstract

Keratoconjunctivitis sicca (KCS) is a common complication of graft-versus-host disease (GVHD), and may lead to corneal epithelial defect and melting. In contrast, recurrent corneal calcareous degeneration and perforation is rare. A 46-year-old woman developed chronic GVHD after bone marrow transplantation for aplastic anemia. Severe KCS with corneal melting and calcium deposits were noted in the left eye. Penetrating keratoplasty was performed because of corneal perforation, but poor re-epithelialization and calcium deposition recurred. Lamellar keratectomy and amniotic membrane transplantation (AMT) were performed, but acute calcareous degeneration developed with subsequent recurrence of corneal perforation. After regraft, AMT and tarsorrhaphy, the corneal graft remained clear for 3 months. However, breakdown of the corneal epithelium occurred 3 weeks after spontaneous separation of tarsorrhaphy. Six months later, corneal perforation recurred again along with exacerbation of GVHD. Regraft was performed, but the patient refused tarsorrhaphy and AMT. Poor re-epithelialization persisted after regraft. Corneal melting with impending corneal perforation ensued. Further corneal surgery was refused and the patient chose to undergo ev...Continue Reading

References

Jan 1, 1987·Cornea·R J Duffey, J A LoCascio
Aug 1, 1993·The British Journal of Ophthalmology·J D HeathW E Schulenburg
Sep 30, 1999·The British Journal of Ophthalmology·Y OgawaK Tsubota
Jun 1, 2000·Bone Marrow Transplantation·E M RochaC A de Souza
Aug 17, 2001·Current Opinion in Ophthalmology·K C SippelC S Foster
Nov 1, 2001·Journal of Cataract and Refractive Surgery·R A EifermanR E Nordquist
Feb 13, 2003·Ophthalmology·Ashok SharmaAmod Gupta
Jan 9, 2004·Survey of Ophthalmology·Harminder S DuaV Senthil Maharajan
Apr 27, 2004·Experimental Eye Research·James P McCulley, Ward E Shine

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Citations

Apr 7, 2009·Néphrologie & thérapeutique·Rim LimaiemLeila El Matri
Nov 26, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T Dietrich-Ntoukas, P Steven
Jun 29, 2010·American Journal of Ophthalmology·Yan-Ming ChenWei-Li Chen
Nov 15, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Amr NassarMahmoud Aljurf
Oct 20, 2007·Oral Diseases·J Lew, J A Smith
May 31, 2018·The British Journal of Ophthalmology·Deepali SinghalNamrata Sharma
May 19, 2011·Expert Opinion on Drug Metabolism & Toxicology·Paul J Jannetto, Nancy C Bratanow
Jul 12, 2017·Frontiers in Medicine·Jiefeng TongXiuming Jin
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Kiumars ShamlooAjay Sharma
Jul 3, 2021·International Journal of Molecular Sciences·Yoko OgawaKazuo Tsubota
Jul 28, 2020·American Journal of Ophthalmology·Shruti SinhaReza Dana
Jul 7, 2021·Ocular Immunology and Inflammation·Jimena Tatiana Carreno-GaleanoReza Dana

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