PMID: 7522002Sep 1, 1994Paper

Recurrent cutaneous necrotizing eosinophilic vasculitis. A novel eosinophil-mediated syndrome

Archives of Dermatology
K R ChenK M Leiferman

Abstract

Review of skin biopsy specimens showing necrotizing vasculitis revealed three patients with small dermal vessel eosinophilic vasculitis and common clinical features characterized by glucocorticoid responsive pruritic erythematous, purpuric papules and angioedema associated with peripheral blood eosinophilia. Indirect immunofluorescent localization of eosinophil granule proteins, neutrophil granule proteins, and mast cell tryptase, electron-microscopic evaluation and immunoperoxidase staining for vascular cell adhesion molecule type 1, intercellular adhesion molecule type I, endothelial-leukocyte adhesion molecule type 1, and very-late activation antigen type 4 were performed. Eosinophil-active cytokines in serum were evaluated by an eosinophil survival assay. Eight skin biopsy specimens from the three patients all showed small-vessel necrotizing vasculitis with exclusive eosinophil infiltration. Ultrastructural study demonstrated degenerating eosinophils and eosinophil granules in proximity to damaged endothelium. The affected small vessels showed marked deposition of the toxic eosinophil granule major basic protein in the vessel walls and expression of vascular cell adhesion molecule type 1 and intercellular adhesion molecule ...Continue Reading

Citations

Oct 27, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P-G SatorF Breier
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Kristin M Leiferman, Gerald J Gleich
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Arjun Datt LawPankaj Malhotra
Apr 9, 2016·Indian Journal of Dermatology·Najeeba RiyazKrishnakumari Nair Silpa
Sep 18, 2007·Immunology and Allergy Clinics of North America·Kristin M LeifermanMargot S Peters
Sep 18, 2007·Immunology and Allergy Clinics of North America·Thomas B Nutman
May 27, 2004·The Journal of Dermatology·Mi-Woo LeeJai-Kyoung Koh
Nov 18, 2003·The British Journal of Dermatology·Y Sakuma-OyamaF Kaneko
Apr 19, 2008·The Journal of Dermatology·Masahiro HayashiTamio Suzuki
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·B S Bochner, R P Schleimer
May 4, 2004·Immunology and Allergy Clinics of North America·Mark D P Davis, Jerry D Brewer
Mar 18, 2011·Actas dermo-sifiliográficas·J J Ríos-MartínD Moreno-Ramírez
Apr 17, 2015·Clinical Reviews in Allergy & Immunology·Hai LongQianjin Lu
Oct 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gudrun RatzingerBernhard Zelger
Mar 17, 2004·The American Journal of Dermatopathology·Mario MagañaJorge Cazarín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Journal of the American Academy of Dermatology
K R ChenK M Leiferman
Contact Dermatitis
Pedro Sánchez SambucetyManuel Angel Rodríguez Prieto
The American Journal of Dermatopathology
Franco RongiolettiAurora Parodi
© 2021 Meta ULC. All rights reserved