Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma

American Journal of Clinical Pathology
Matthew M KlairmontJoel F Gradowski

Abstract

Data characterizing the cytogenetic landscape of intravascular large B-cell lymphoma (ILBCL) are limited. Here, we developed a comprehensive karyotypic data set to identify recurrent cytogenetic abnormalities in ILBCL. Cases of ILBCL with complete cytogenetic analysis were identified from an institutional database and the literature. The combined data were systematically reviewed for the presence of recurrent abnormalities. Four new cases were identified and combined with 25 karyotypes previously published in the literature. Karyotypes were uniformly complex with a median of 10 aberrations. In total, 72.4% had abnormalities involving chromosome 1, with 31.0% involving rearrangements of 1p13 or 1q21; 58.6% had abnormalities involving chromosome 6, which in almost all cases involved 6q; 34.5% had abnormalities involving chromosome 14, with 27.6% involving rearrangements of 14q32; and 55.2% had abnormalities of chromosome 18, with 37.9% harboring trisomy 18. Recurrent cytogenetic abnormalities involving chromosomes 1, 6q, and 18 are present in greater than 50% of ILBCL.

References

Mar 25, 1999·European Journal of Haematology·M JerkemanF Mitelman
Aug 8, 2001·American Journal of Clinical Pathology·H C BertramM A Milano
Apr 11, 2002·American Journal of Clinical Oncology·Akihiro TsukadairaKeishi Kubo
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Haytham KhouryDouglas E Horsman
Oct 6, 2004·British Journal of Haematology·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Feb 24, 2006·The Journal of Experimental Medicine·Laura PasqualucciRiccardo Dalla-Favera
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurilio PonzoniShigeo Nakamura
Jul 4, 2007·Haematologica·Yuanping ZhouMing-Qing Du
Oct 20, 2010·Annals of Hematology·Kosei MatsueMasami Takeuchi
Sep 17, 2011·Internal Medicine·Taishi Kobayashi, Hitoshi Ohno
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Can KüçükWing C Chan
Aug 15, 2012·The Journal of Experimental Medicine·Mark J KielKojo S J Elenitoba-Johnson
Sep 3, 2013·Journal of Clinical and Experimental Hematopathology : JCEH·Katsuya YamamotoHironobu Minami
Mar 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marina ParryJonathan C Strefford
Jun 24, 2016·Blood·Valeria SpinaDavide Rossi
Oct 30, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fabian BockMuzaffar H Qazilbash

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Citations

Aug 9, 2020·Journal of Clinical Pathology·Kohei FujikuraYukihiro Imai
Nov 19, 2019·Pathology·Narittee SukswaiL Jeffrey Medeiros
Apr 29, 2020·Biomedical Journal·Yuen-Chin OngMing-Chung Kuo

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