Recurrent diaphragmatic hernia: Modifiable and non-modifiable risk factors

Pediatric Pulmonology
Montaha M Al-IedeDominic A Fitzgerald

Abstract

The risk of recurrence of Congenital Diaphragmatic Hernia (CDH) in an era of thoracoscopic surgery is unclear. (1) estimate the incidence and (2) evaluate the perioperative factors associated with the symptomatic recurrence of CDH. Medical records of CDH infants operated on in the neonatal period at a single-tertiary hospital between January 2000 and January 2013 were retrospectively reviewed. Of 119 infants with CDH, 34 (28.6%) were excluded: 17 (14.3%) died without recurrence and 17 (14.3%) presented beyond neonatal period or were followed elsewhere. Of 85 survivors, 71 infants had an open repair and 14 had a thoracoscopic repair. Eleven of 85 survivors (13%) developed a recurrence on average 19.8 weeks (range 15-34) after the initial repair. Of 11 recurrences, 6 had an initial thoracoscopic repair and 5 had an open repair (6/14 [43%] vs. 5/71 [7%]; P = 0.002). Two children had multiple recurrences. Statistically significant associations were found between recurrence and the presence of persistent pulmonary hypertension (PPHTN) (P = 0.006), severe PPHTN (P = 0.002), inhaled nitric oxide, or sildenafil use for treatment of PPHTN (P = 0.002), need for perioperative high frequency oscillatory ventilation (HFOV) (P = 0.0006), len...Continue Reading

References

Feb 1, 1981·Journal of Pediatric Surgery·D Cohen, I S Reid
Jun 1, 1996·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·L M de Kort, K M Bax
Jul 11, 1998·Journal of Pediatric Surgery·P EghtesadyW D Rhine
Feb 2, 1999·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·G F HajerC Festen
Feb 24, 2000·Journal of Perinatology : Official Journal of the California Perinatal Association·I P SchwartzR A Polin
Jan 11, 2001·Journal of Pediatric Surgery·R L MossM R Harrison
Dec 6, 2001·Journal of Pediatric Surgery·D A SaltzmanC W Wagner
May 3, 2003·Seminars in Pediatric Surgery·Dorothy H Rowe, Charles J Stolar
May 4, 2005·Journal of Pediatric Surgery·Raul A CortesKerilyn K Nobuhara
May 19, 2007·The Journal of Surgical Research·Shawn D St PeterCharles L Snyder
Sep 4, 2007·Pediatrics·UNKNOWN Congenital Diaphragmatic Hernia Study GroupRonald B Hirschl
Oct 9, 2008·Pediatric Surgery International·M G PeetsoldR J B J Gemke
Jun 16, 2009·Journal of Pediatric Surgery·Jason C FisherMarc S Arkovitz
Jan 29, 2010·Journal of Pediatric Surgery·Tim JancelewiczKerilyn Nobuhara
Oct 19, 2010·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·C A LaituriS D St Peter
Jun 21, 2011·Journal of Pediatric Surgery·KuoJen TsaoUNKNOWN Congenital Diaphragmatic Hernia Study Group
Apr 14, 2012·Journal of Pediatric Surgery·Jacqueline TsaiAlan W Flake
Jul 13, 2013·Journal of Pediatric Surgery·Ryan P CauleyUNKNOWN Congenital Diaphragmatic Hernia Study Group
Nov 15, 2013·The British Journal of Surgery·W B JawaidP D Losty
May 24, 2014·Journal of Pediatric Surgery·Emily ChanAhmed Nasr
Dec 20, 2014·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Kouji NagataTomoaki Taguchi
Mar 15, 2015·Paediatric Respiratory Reviews·Perraju BendapudiAnne Greenough

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Citations

Sep 8, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Katrina L WeaverShawn D St Peter
Jan 4, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Heather L ShortAvraham Schlager
Oct 10, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Miao YuanGang Yang
May 23, 2019·Clinical Pediatrics·Savannah Ellis, Sasikumar Kilaikode
Oct 3, 2018·Bioinorganic Chemistry and Applications·Gamil A Al-HazmiKamel A Saleh
Nov 28, 2020·Pediatric Surgery International·Irene de Haro JorgeXavier Tarrado
Mar 6, 2021·La Pediatria medica e chirurgica : Medical and surgical pediatrics·Żaneta Słowik-Moczydłowska, Andrzej Kamiński

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