Recurrent Endocarditis in Persons Who Inject Drugs

Open Forum Infectious Diseases
Laura RodgerMichael Silverman


Infective endocarditis (IE) is increasing among persons who inject drugs (PWID) and has high morbidity and mortality. Recurrent IE in PWID is not well described. This was a retrospective cohort study conducted between February 2007 and March 2016. It included adult inpatients (≥18) at any of 3 tertiary care centers in London, Ontario, with definite IE based on the Modified Duke's Criteria. The objectives were to characterize recurrent IE in PWID, identify risk factors for recurrent IE, identify the frequency of fungal endocarditis, and establish whether fungal infection was associated with higher mortality. Three hundred ninety patients had endocarditis, with 212/390 in PWID. Sixty-eight of 212 (32%) PWID had a second episode, with 28/212 (12%) having additional recurrences. Second-episode IE was more common in PWID (11/178 [6.2%] vs 68/212 [32.1%]; P < .001). Peripherally inserted central catheter (PICC) line abuse was associated with increased risk of recurrent endocarditis (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.01-3.87; P = .04). In PWID, fungal IE was more common in second episodes than first episodes (1/212 [0.5%] vs 5/68 [7.4%]; P = .004). Additionally, fungal infections were associated with mortality in ...Continue Reading

Associated Clinical Trials


Jun 1, 1979·The American Journal of Medicine·D E WeltonR R Miller
Oct 1, 1993·Postgraduate Medical Journal·I S Lossos, R Oren
Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E EllisW Ventura
Jul 13, 2002·Chest·Lígia C Pierrotti, Larry M Baddour
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vivian H ChuChristopher W Woods
Dec 23, 2006·The Annals of Thoracic Surgery·Scott P KaiserJennifer S Lawton
Mar 11, 2009·Archives of Internal Medicine·David R MurdochUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
Apr 29, 2010·Journal of General Internal Medicine·Justin M GlasgowPeter J Kaboli
Nov 17, 2011·The Journal of Antimicrobial Chemotherapy·F Kate Gould Working Party of the British Society for Antimicrobial Chemotherapy
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L AlagnaV H Chu
May 6, 2014·The Annals of Thoracic Surgery·Sarah C Hull, Farid Jadbabaie
Jun 27, 2014·Mycopathologia·Spinello AntinoriLaura Milazzo
Sep 3, 2014·International Journal of Antimicrobial Agents·Pierre TattevinOlivier Lortholary
Apr 8, 2015·International Journal of Cardiology·Carlos Ortiz-BautistaJosé Alberto San Román
Sep 6, 2015·Lancet·Thomas J Cahill, Bernard D Prendergast
Sep 17, 2015·Circulation·Larry M BaddourUNKNOWN American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Jan 1, 2016·Postgraduate Medical Journal·Thomas ColvilleKhaled Albouaini
Jan 31, 2016·Interactive Cardiovascular and Thoracic Surgery·Oda Bratland ØsterdalRune Haaverstad
Nov 2, 2016·Open Forum Infectious Diseases·Alysse G WurcelThomas J Stopka
Apr 4, 2017·The Journal of Thoracic and Cardiovascular Surgery·UNKNOWN AATS Surgical Treatment of Infective Endocarditis Consensus Guidelines Writing Committee ChairsLaila E Woc-Colburn
May 23, 2017·Drug and Alcohol Dependence·Christopher M JonesR Matthew Gladden
Jun 7, 2017·Harm Reduction Journal·Malika SharmaAhmed M Bayoumi
Dec 18, 2018·Open Forum Infectious Diseases·Glen HuangJames E Peacock
Jan 30, 2019·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Matthew A WeirMichael Silverman
Jul 4, 2019·MMWR. Morbidity and Mortality Weekly Report·Kathleen P HartnettGhinwa Dumyati

❮ Previous
Next ❯


May 6, 2020·International Journal of Legal Medicine·Federico ManettiStefano D'Errico
Feb 5, 2021·Journal of the American College of Cardiology·Juan M PericàsUNKNOWN International Collaboration on Endocarditis (ICE) Investigators
Aug 13, 2020·Infectious Disease Clinics of North America·Asher Schranz, Joshua A Barocas

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.