PMID: 2122399Apr 1, 1990Paper

Recurrent epistaxis, chronic pancytopenia and nasal mycosis

Pathology
K BaumgartW Benson

Abstract

A 52-year-old man with chronic, profound pancytopenia associated with a four-year history of Waldenstrom's macroglobulinemia refractory to chemotherapy began to experience major epistaxes requiring hospital admission for control. A diagnosis of invasive Aspergillus was made on nasal mucosal biopsy. A regimen of bi-weekly intravenous and sixth-hourly topical amphotericin B drops with adjuvant rifampicin successfully eradicated local nasal pain as well as the epistaxis. Resolution of infection was documented by gallium scan. It is suggested that, in addition to the aggressive craniofacial mycoses already described, lower grade nasal mycoses occur. The roles of biopsy and gallium scan in immunocompromised hosts with epistaxis are discussed.

References

Jun 1, 1986·Australian and New Zealand Journal of Medicine·P Hersey
Aug 1, 1985·The Laryngoscope·M F Colman
Sep 1, 1985·Radiology·W KoppH Stammberger
Jan 1, 1973·The American Journal of Medicine·R D MeyerB Yu
May 1, 1984·Southern Medical Journal·M C Zarabi, S Salmassi

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Citations

Feb 3, 2000·Seminars in Nuclear Medicine·C H Kao

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.