PMID: 9649647Jul 3, 1998Paper

Recurrent hepatitis C virus infection after liver transplantation: immunohistochemical assessment of the viral antigen

Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
V VargasJ Guardia

Abstract

The value of immunohistochemical methods to identify hepatitis C virus antigen (HCVAg) in liver tissue has not been established. We have evaluated the significance of HCVAg expression in livers of patients with transplants and recurrent hepatitis C virus (HCV) infection. Forty-two liver biopsy specimens from 32 liver-transplant recipients with recurrent HCV infection were tested for HCVAg using fluorescein isothiocyanate-labeled polyclonal, polyreactive human immunoglobulin. Histologic assessment of liver and quantitation of HCV RNA in sera were carried out in specimens obtained simultaneously with biopsies. HCVAg was found in 33% of the liver specimens obtained during the first month after transplantation and in all liver specimens obtained between 1 and 18 months after transplantation. Amounts of the antigen were significantly greater in specimens obtained more than 1 month after transplantation. A statistically significant increase of the average HCV RNA level in serum was observed in samples tested after the first month after the transplantation, and some decrease in the HCV RNA level was found in those obtained between 6 and 18 months after transplantation. Larger amounts of HCVAg were observed in specimens corresponding t...Continue Reading

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Citations

Sep 2, 1998·Transplantation Proceedings·N S CookH J Schuurman
Nov 3, 2001·Journal of Hepatology·M BerenguerT L Wright
Sep 15, 2000·Infectious Disease Clinics of North America·H R Rosen, P Martin
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D R Abraczinskas, R T Chung
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S GawecoD H Van Thiel
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giorgio BallardiniFrancesco Bianco Bianchi
Mar 25, 2014·World Journal of Gastroenterology : WJG·Francesco VasuriAntonia D'Errico-Grigioni
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael G HughesTimothy L Pruett
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael G Hughes, Hugo R Rosen
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael G HughesTimothy L Pruett
Oct 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Lydia M Petrovic
Oct 13, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alberto GrassiGiorgio Ballardini
Aug 30, 2014·World Journal of Gastroenterology : WJG·Alberto Grassi, Giorgio Ballardini
Jan 31, 2002·World Journal of Gastroenterology : WJG·Z Q SongG D Liu

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