Recurrent Hepatocellular Carcinoma in Patient with Crohn's Disease: Incidental or Expected Outcome of Azathioprine?

Case Reports in Gastrointestinal Medicine
Youssef BotrosAndrew de la Torre

Abstract

Hepatocellular carcinoma (HCC) usually occurs in patients with underlying risk factors such as liver cirrhosis and chronic hepatitis B. Although patients with Crohn's disease (CD) are at an increased risk to develop malignancies such as colon cancer, the incidence of HCC in this population is extremely rare. We report a case of 62-year-old male with long history of CD treated with azathioprine (AZA) and aminosalicylic acid (ASA) who was incidentally diagnosed with HCC, for which left hepatectomy was done. Four years later during routine follow-up, patient had another hepatic lesion and underwent resection of the mass. The mechanism of occurrence of HCC in patient with CD is still controversial and may include immune mediated changes and medication related complications. AZA was reported in all case reports of CD that developed HCC. Through this report we hope to explore the complex pathophysiological mechanisms contributing to the development of HCC in the Crohn's disease patient population.

References

Oct 1, 1991·Gastroenterology·N ArberY Sidi
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P BraletB Terris
Oct 30, 2001·Digestive Diseases and Sciences·M L Borum
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Apr 4, 2007·Digestive Diseases and Sciences·Jason Samarasena, Mark Borgaonkar
Sep 4, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HemminkiK Sundquist
May 16, 2009·Internal Medicine·Hideaki MiuraHaruki Yamada
Jul 1, 2009·Pathology International·Ayumi MurakamiAkinori Nozawa
Jul 2, 2010·World Journal of Gastroenterology : WJG·Mitsuaki IshidaHidetoshi Okabe
Sep 14, 2011·World Journal of Gastroenterology : WJG·Shu-Mei ZhengQin Ouyang
Dec 12, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J M P A van den ReekE M G J de Jong
Jun 1, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David S KotlyarGary R Lichtenstein

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Citations

Aug 26, 2021·Curēus·Akira HokamaJiro Fujita

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