Recurrent interactions in local cortical circuits.

Nature
Simon P PeronKarel Svoboda

Abstract

Most cortical synapses are local and excitatory. Local recurrent circuits could implement amplification, allowing pattern completion and other computations1-4. Cortical circuits contain subnetworks that consist of neurons with similar receptive fields and increased connectivity relative to the network average5,6. Cortical neurons that encode different types of information are spatially intermingled and distributed over large brain volumes5-7, and this complexity has hindered attempts to probe the function of these subnetworks by perturbing them individually8. Here we use computational modelling, optical recordings and manipulations to probe the function of recurrent coupling in layer 2/3 of the mouse vibrissal somatosensory cortex during active tactile discrimination. A neural circuit model of layer 2/3 revealed that recurrent excitation enhances sensory signals by amplification, but only for subnetworks with increased connectivity. Model networks with high amplification were sensitive to damage: loss of a few members of the subnetwork degraded stimulus encoding. We tested this prediction by mapping neuronal selectivity7 and photoablating9,10 neurons with specific selectivity. Ablation of a small proportion of layer 2/3 neurons...Continue Reading

References

Aug 18, 1995·Science·R J DouglasH H Suarez
Apr 9, 1999·Nature Neuroscience·F S ChanceL F Abbott
Jun 13, 2003·Biomedical Engineering Online·Thomas A PologrutoKarel Svoboda
Jun 19, 2003·The Journal of Physiology·Carl HolmgrenYuri Zilberter
Nov 24, 2006·PLoS Biology·Ingrid BureauKarel Svoboda
Jul 17, 2007·Journal of Computational Neuroscience·Romain BretteAlain Destexhe
Feb 12, 2008·Nature Neuroscience·Michael B OrgerFlorian Engert
Feb 27, 2008·Network : Computation in Neural Systems·Misha B AhrensManeesh Sahani
Mar 10, 2009·Nature Neuroscience·John C Curtis, David Kleinfeld
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel H O'ConnorKarel Svoboda
Dec 31, 2010·Nature Methods·Simon Peron, Karel Svoboda
Mar 26, 2011·Neuron·Sylvain CrochetCarl C H Petersen
Mar 10, 2012·Journal of Neurophysiology·Michael AvermannCarl C H Petersen
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Hansel, Carl van Vreeswijk
Jul 14, 2012·PLoS Computational Biology·Nathan G ClackEugene W Myers
Sep 25, 2012·Nature Neuroscience·Ashok Litwin-Kumar, Brent Doiron
Apr 16, 2013·Neuron·Carl C H Petersen, Sylvain Crochet
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Aug 13, 2013·Nature Neuroscience·Anthony D Lien, Massimo Scanziani
Nov 10, 2013·Nature·Kenneth D Harris, Thomas D Mrsic-Flogel
Dec 24, 2013·Neuron·Zengcai V GuoKarel Svoboda
Feb 13, 2014·PloS One·Zengcai V GuoKarel Svoboda
Jul 22, 2014·Nature·Mingshan XueMassimo Scanziani
Aug 8, 2015·ELife·Samuel Andrew HiresKarel Svoboda
Feb 13, 2016·Current Opinion in Neurobiology·Kenneth D Miller
Mar 29, 2016·Nature·Wei-Chung Allen LeeR Clay Reid
Dec 10, 2016·ELife·David Gt BarrettChristian K Machens
May 19, 2017·Journal of Neurophysiology·Ian K ChristieStephen D Van Hooser
Mar 8, 2019·Nature·Selmaan N Chettih, Christopher D Harvey
Jul 20, 2019·Science·James H MarshelKarl Deisseroth
Aug 2, 2019·Nature Reviews. Neuroscience·Carl C H Petersen
Aug 21, 2019·ELife·Marcel StimbergDan Fm Goodman

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Citations

Apr 24, 2020·ELife·Alessandro Sanzeni, Mark H Histed
Aug 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·David J Heeger, Klavdia O Zemlianova
Jul 10, 2020·Annual Review of Neuroscience·David H Brann, Sandeep Robert Datta
Jan 27, 2021·Nature Neuroscience·Kayvon DaieShaul Druckmann
Oct 27, 2020·ELife·Henry Wp DalgleishMichael Häusser
Nov 13, 2020·Nature Reviews. Neuroscience·Sadra Sadeh, Claudia Clopath
Feb 21, 2021·Cell Calcium·Nazanin DoostdarSamuel J Barnes
May 12, 2021·ACS Applied Materials & Interfaces·Tao LuChaobo Huang
Apr 23, 2020·Current Opinion in Neurobiology·Luis Carrillo-Reid, Rafael Yuste
Aug 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Wolf Singer

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Methods Mentioned

BETA
transgenic

Software Mentioned

Brian2

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